Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

被引：39

作者：

Mascolo, Ludovica ^{[1
]}

Bald, Dirk ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Fac Sci, Amsterdam Inst Mol Med & Syst, Dept Mol Cell Biol, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2020年 / 152卷

基金：

欧盟地平线“2020”;

关键词：

Cytochrome bd; Mycobacterium tuberculosis; Respiratory chain; Antibacterials; ESCHERICHIA-COLI; ENERGY-METABOLISM; QUINOL OXIDASE; ATP SYNTHASE; IN-VITRO; OXYGEN; PURIFICATION; COMPLEX; DIARYLQUINOLINES; FLEXIBILITY;

D O I：

10.1016/j.pbiomolbio.2019.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of the mammalian host and in the defense against antibacterials. Deeper insight into the biochemistry of mycobacterial cytochrome bd is needed to understand the physiological role of this bacteria-specific defense factor. Conversely, cytochrome bd may be utilized to gain information on mycobacterial physiology in vitro and during host infection. Knowledge-based manipulation of cytochrome bd function may assist in designing the next-generation tuberculosis combination chemotherapy. (C) 2019 The Authors. Published by Elsevier Ltd.

引用

页码：55 / 63

页数：9

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