Clinical Influence of Ploidy and Cancer Stem Cells and Other Parameters in Stage IV Colorectal Cancer

被引：2

作者：

Polyzos, Konstantinos A. ^{[1
]}

Karadima, Maria L. ^{[2
]}

Kosma, Aikaterini C. ^{[3
]}

Lazaris, Andreas ^{[1
]}

Kavantzas, Nikolaos ^{[4
]}

Tsavaris, Nikolas ^{[2
]}

机构：

[1] Univ Athens, Dept Internal Med, Fac Med, Athens, Greece

[2] Univ Athens, Dept Pathophysiol, Fac Med, Athens, Greece

[3] Gen Hosp Nikaia, Div Internal Med 2, Piraeus, Greece

[4] Univ Athens, Dept Pathol, Fac Med, Athens, Greece

来源：

IN VIVO | 2019年 / 33卷 / 01期

关键词：

Colorectal cancer; prognosis; stem cells; ploidy; EXPRESSION; SURVIVAL;

D O I：

10.21873/invivo.11467

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: The aim of the present study was the evaluation of the influence of cancer stem cells and other parameters in stage IV colorectal cancer patients. Materials and Methods: One hundred patients were retrospectively included in the study and 24 variables were examined for their relation with response to treatment and survival. Results: A low ploidy score in the histology of colorectal cancer was associated with improvement of performance status and response to therapy. No significant correlations between the percentage of cancer stem cells from the same tissue and the remaining clinical parameters was revealed. In the multivariate analysis of all the examined parameters in Cox models, independent unfavorable prognostic factors were increased ploidy score, existence of bone metastases, use of epoetin, and existence of side-effects such as anorexia, mucositis, and weight loss. Conclusion: Our findings emphasize on the prognostic role of ploidy in advanced colorectal cancer, but further analysis is required to evaluate the role of cancer stem cells.

引用

页码：245 / 249

页数：5

共 18 条

[1] Serum and tissue markers in colorectal cancer: State of art
Berretta, Massimiliano
Alessandrini, Lara
De Divitiis, Chiara
Nasti, Guglielmo
Lleshi, Arben
Di Francia, Raffaele
Facchini, Gaetano
Cavaliere, Carla
Buonerba, Carlo
Canzonieri, Vincenzo
[J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2017, 111 : 103 - 116
[2] Chelidonis G, 2009, ANAL QUANT CYTOL, V31, P332
[3] Phenotypic characterization of human colorectal cancer stem cells
Dalerba, Piero
Dylla, Scott J.
Park, In-Kyung
Liu, Rui
Wang, Xinhao
Cho, Robert W.
Hoey, Timothy
Gurney, Austin
Huang, Emina H.
Simeone, Diane M.
Shelton, Andrew A.
Parmiani, Giorgio
Castelli, Chiara
Clarke, Michael F.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) : 10158 - 10163
[4] CD44 is of Functional Importance for Colorectal Cancer Stem Cells
Du, Lei
Wang, Hongyi
He, Leya
Zhang, Jingyu
Ni, Biyun
Wang, Xiaohui
Jin, Haijing
Cahuzac, Nathalie
Mehrpour, Maryam
Lu, Youyong
Chen, Quan
[J]. CLINICAL CANCER RESEARCH, 2008, 14 (21) : 6751 - 6760
[5] Eker Baki, 2015, Asian Pac J Cancer Prev, V16, P3015
[6] Prognostic value of CD133+CD54+CD44+ circulating tumor cells in colorectal cancer with liver metastasis
Fang, Chao
Fan, Chuanwen
Wang, Cun
Huang, Qiaorong
Meng, Wentong
Yu, Yongyang
Yang, Lie
Hu, Jiankun
Li, Yuan
Mo, Xianming
Zhou, Zongguang
[J]. CANCER MEDICINE, 2017, 6 (12): : 2850 - 2857
[7] Genomic and epigenetic instability in colorectal cancer pathogenesis
Grady, William M.
Carethers, John M.
[J]. GASTROENTEROLOGY, 2008, 135 (04) : 1079 - 1099
[8] CD133 expression in chemo-resistant Ewing sarcoma cells
Jiang, Xiaohua
Gwye, Ynnez
Russell, Darren
Cao, Christine
Douglas, Dorothea
Hung, Long
Kovar, Heinrich
Triche, Timothy J.
Lawlor, Elizabeth R.
[J]. BMC CANCER, 2010, 10
[9] The Prognostic Influence of BRAF Mutation and other Molecular, Clinical and Laboratory Parameters in Stage IV Colorectal Cancer
Karadima, Maria L.
Saetta, Angelica A.
Chatziandreou, Ilenia
Lazaris, Andreas C.
Patsouris, Efstratios
Tsavaris, Nikolaos
[J]. PATHOLOGY & ONCOLOGY RESEARCH, 2016, 22 (04) : 707 - 714
[10] CD133: A stem cell biomarker and beyond
Li Z.
[J]. Experimental Hematology & Oncology, 2 (1)

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