Convenient Synthesis of Novel Nitrogen Bridgehead Heterocycles Utilizing 3-Mercapto-6H-[1,2,4,5]oxatriazino[3,2-a]isoindol-6-one as a New Synthon

Considering oxatriazino[a]isoindole as a wealthy structure for developing molecules of impressive therapeutic potentials, some new oxatriazino[3,2-a]isoindoles analogs were synthesized. Thus, 3-mercapto-6H-[1,2,4,5]oxatriazino[3,2-a]isoindol-6-one (5), was prepared as one-pot three-components product and subjected to a series of manipulations including cycloaddition reactions to annulate a series of pharmacophoric motif conjugates. The structures of the newly synthesized compounds were elucidated based on their correct elemental and spectroscopic data.