Development and Evolution of the Human Neocortex

被引:940
作者
Lui, Jan H. [1 ,2 ,3 ]
Hansen, David V. [1 ,2 ]
Kriegstein, Arnold R. [1 ,2 ]
机构
[1] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA
关键词
RADIAL GLIAL-CELLS; NEURAL STEM-CELLS; OUTER SUBVENTRICULAR ZONE; CEREBRAL CORTICAL SIZE; ALPHA-E-CATENIN; BETA-CATENIN; DEVELOPING MOUSE; VENTRICULAR ZONE; PROGENITOR-CELL; FETAL MONKEY;
D O I
10.1016/j.cell.2011.06.030
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating neurons. Relating these features to other mammalian species and known molecular regulators of the mouse neocortex suggests how this developmental process could have emerged in evolution.
引用
收藏
页码:18 / 36
页数:19
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