Phosphorylation of Glycine Derivatives via Copper(I)-Catalyzed Csp3-H Bond Functionalization

被引：52

作者：

Zhi, Huizhen ^{[1
,2
]}

Ung, Sosthene Pierre-Marie ^{[1
]}

Liu, Yun ^{[1
,3
]}

Zhao, Liang ^{[1
]}

Li, Chao-Jun ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada

[2] Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210046, Jiangsu, Peoples R China

[3] Jiangsu Normal Univ, Inst Chem & Chem Engn, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou, Jiangsu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 15期

基金：

加拿大自然科学与工程研究理事会;

关键词：

aminophosphonates; copper; glycine derivatives; organophosphorus compounds; phosphorylation; PALLADIUM-CATALYZED PHOSPHONATION; LIGHT-EMITTING-DIODES; (E)-1-ALKENYLPHOSPHINE OXIDES; COUPLING REACTIONS; H-PHOSPHONATES; C-C; ACIDS; SILVER; CONSTRUCTION; PHOSPHITES;

D O I：

10.1002/adsc.201600539

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and efficient one-pot approach has been developed for a copper-catalyzed phosphorylation of glycine derivatives under air and at room temperature. The present cross-dehydrogenative coupling allows various methoxyphenyl-protected glycine derivatives to be phosphorylated using diverse alkyl and aryl phosphites through an oxidative coupling between Csp(3)-H and P-H bonds catalyzed by copper iodide. This method provides a new synthetic tool to obtain biologically active alpha-aminophosphonates.

引用

页码：2553 / 2557

页数：5

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