The Prognosis and Recurrence Pattern of Right- and Left-Sided Colon Cancer in Stage II, Stage III, and Liver Metastasis After Curative Resection

被引：29

作者：

Nakamura, Yasuyuki ^{[1
]}

Hokuto, Daisuke ^{[1
]}

Koyama, Fumikazu ^{[1
]}

Matsuo, Yasuko ^{[1
]}

Nomi, Takeo ^{[1
]}

Yoshikawa, Takahiro ^{[1
]}

Kamitani, Naoki ^{[1
]}

Sadamitsu, Tomomi ^{[1
]}

Takei, Takeshi ^{[1
]}

Matsumoto, Yayoi ^{[1
]}

Iwasa, Yosuke ^{[1
]}

Fukuoka, Kohei ^{[1
]}

Obara, Shinsaku ^{[1
]}

Nakamoto, Takayuki ^{[1
]}

Kuge, Hiroyuki ^{[1
]}

Sho, Masayuki ^{[1
]}

机构：

[1] Nara Med Univ, Dept Surg, 840 Shijo Cho, Kashihara, Nara 6348522, Japan

来源：

ANNALS OF COLOPROCTOLOGY | 2021年 / 37卷 / 05期

关键词：

Right-sided colon cancer; Left-sided colon cancer; Colorectal liver metastasis; PRIMARY TUMOR LOCATION; MICROSATELLITE INSTABILITY; IMPACT; SURVIVAL; DISTAL; SURGERY;

D O I：

10.3393/ac.2020.09.14

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose: Primary tumor location of colon cancer has been reported to affect the prognosis after curative resection. However, some reports suggested the impact was varied by tumor stage. This study analyzed the prognostic impact of the sidedness of colon cancer in stages II, III, and liver metastasis after curative resection using propensity-matched analysis. Methods: Right-sided colon cancer was defined as a tumor located from cecum to splenic flexure, while any more distal colon cancer was defined as left-sided colon cancer. Patients who underwent curative resection at Nara Medical University hospital between 2000 and 2016 were analyzed. Results: There were 110 patients with stage II, 100 patients with stage III, and 106 patients with liver metastasis. After propensity matching, 28 pairs with stage II and 32 pairs with stage III were identified. In the patients with stage II, overall survival (OS) and recurrence-free survival (RFS) were not significantly different for right-and left-sided colon cancers. In the patients with stage III, OS and RFS were significantly worse in right-sided colon cancer. In those with liver metastasis, OS of right-sided colon cancer was significantly worse than left-sided disease, while RFS was similar. Regarding metachronous liver metastasis, the difference was observed only in the patients whose primary colon cancer was stage III. In each stage, significantly higher rate of peritoneal recurrence was found in those with right-sided colon cancer. Conclusion: Sidedness of colon cancer had a significant and varied prognostic impact in patients with stage II, III, and liver metastasis after curative resection.

引用

页码：326 / 336

页数：11

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