Two-dimensional FT-ICR/MS with IRMPD as fragmentation mode

被引：30
|
作者：
van Agthoven, Maria A. [1 ,2 ]
Delsuc, Marc-Andre [3 ]
Rolando, Christian [1 ,2 ]
机构：
[1] Univ Lille 1 Sci & Technol, CNRS, USR 3290, Miniaturisat Syst Analyse & Proteom, F-59655 Villeneuve Dascq, France
[2] Univ Lille 1 Sci & Technol, CNRS, FR 2638, Inst Michel Eugene Chevreul, F-59655 Villeneuve Dascq, France
[3] Inst Genom & Biol Mol & Cellulaire, Illkirch Graffenstaden, France
来源：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2011年 / 306卷 / 2-3期
关键词：
FT-ICR; 2-Dimensional; IRMPD; FTMS; Pulse sequence; Double-frequency; RESONANCE MASS-SPECTROMETRY; INFRARED MULTIPHOTON DISSOCIATION; HADAMARD-TRANSFORM; ION; NMR; NOISE; ELUCIDATION; ENHANCEMENT; MODULATION; PEPTIDES;
D O I：
10.1016/j.ijms.2010.10.034
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
In 1988, Gaumann et al. introduced a pulse sequence for two-dimensional FT-ICR/MS correlating parent ions and fragment ions without the need for ion isolation. The improvement in computer technology makes this pulse sequence analytically useful in order to obtain structural information on complex samples. The pulse sequence can be applied to all cyclotron radius-dependent fragmentation modes, including gas-free fragmentation modes like IRMPD, which do not affect sensitivity and resolving power like the pulsing of a gas into the ICR cell does. This study shows the feasibility of 2D FT-ICR/MS and lays the groundwork to turn this method into a viable analytical tool. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：196 / 203
页数：8
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