Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes

被引：59
|
作者：
Fernández, P
Guillén, MI
Gomar, F
Alcaraz, MJ
机构：
[1] Univ Valencia, Dept Farmacol, Fac Farm, E-46100 Burjassot, Valencia, Spain
[2] Univ Cardenal Herrera, CEU, Dept Quim Bioquim & Biol Mol, Fac Ciencias Expt & Salud, Moncada 46100, Valencia, Spain
[3] Univ Valencia, Dept Cirugia, Fac Med, Blasco Ibanez, Valencia, Spain
来源：
BIOCHEMICAL PHARMACOLOGY | 2003年 / 66卷 / 10期
关键词：
heme oxygenase-1; human cartilage; osteoarthritis; chondrocyte; cytokines; nitric oxide;
D O I：
10.1016/S0006-2952(03)00543-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Heme oxygenase-1 (HO-1) is implicated in the protection against tissue injury. We investigated the expression of this protein in cartilage sections and chondrocytes obtained from osteoarthritic patients. HO-I was immunodetected in preparations from cartilage and also in chondrocytes cultured in the absence of stimulation. We found that HO-I can be modulated by cytokines since the pro-inflammatory cytokines interleukin (IL)-1beta, IL-17 and tumour necrosis factor-alpha (TNF-alpha) down-regulated this protein, whereas the anti-inflammatory cytokine IL-10 exerted the opposite effect. Our results suggest a role for HO-1 as part of protective mechanisms against tissue injury in human cartilage. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：2049 / 2052
页数：4
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