Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

被引:39
作者
Beyer, Leonie [1 ]
Nitschmann, Alexander [1 ]
Barthel, Henryk [2 ]
van Eimeren, Thilo [3 ,4 ,5 ,6 ,7 ]
Unterrainer, Marcus [1 ]
Sauerbeck, Julia [1 ]
Marek, Ken [8 ,9 ]
Song, Mengmeng [1 ]
Palleis, Carla [10 ]
Respondek, Gesine [10 ,11 ]
Hammes, Jochen [4 ]
Barbe, Michael T. [5 ,6 ]
Onur, Oezguer [5 ,6 ]
Jessen, Frank [7 ,12 ,13 ]
Saur, Dorothee [14 ]
Schroeter, Matthias L. [15 ,16 ,17 ]
Rumpf, Jost-Julian [13 ]
Rullmann, Michael [2 ]
Schildan, Andreas [2 ]
Patt, Marianne [2 ]
Neumaier, Bernd [18 ,19 ]
Barret, Olivier [8 ,9 ]
Madonia, Jennifer [8 ,9 ]
Russell, David S. [8 ,9 ]
Stephens, Andrew W. [20 ]
Roeber, Sigrun [21 ]
Herms, Jochen [11 ,21 ]
Boetzel, Kai [10 ]
Levin, Johannes [10 ,11 ]
Classen, Joseph [14 ]
Hoeglinger, Guenter U. [11 ,22 ,23 ]
Bartenstein, Peter [1 ,24 ]
Villemagne, Victor [25 ,26 ,27 ]
Drzezga, Alexander [4 ,7 ]
Seibyl, John [8 ,9 ]
Sabri, Osama [2 ]
Brendel, Matthias [1 ,24 ]
机构
[1] Univ Hosp Munich LMU Munich, Dept Nucl Med, Marchioninstr 15, D-81377 Munich, Germany
[2] Univ Leipzig, Dept Nucl Med, Leipzig, Germany
[3] Res Ctr Juelich, Cognit Neurosci, Inst Neurosci & Med INM 3, Julich, Germany
[4] Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany
[5] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany
[6] Univ Hosp Cologne, Cologne, Germany
[7] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
[8] InviCRO LLC, Boston, MA USA
[9] InviCRO, Mol Neuroimaging, New Haven, CT USA
[10] Ludwig Maximilians Univ Munchen, Dept Neurol, Univ Hosp Munich, Munich, Germany
[11] German Ctr Neurodegenerat Dis DZNE, Munich, Germany
[12] Univ Hosp Cologne, Dept Psychiat, Cologne, Germany
[13] Univ Hosp Cologne, Ctr Memory Disorders, Cologne, Germany
[14] Univ Leipzig, Dept Neurol, Med Ctr, Leipzig, Germany
[15] Univ Leipzig, Clin Cognit Neurol, Leipzig, Germany
[16] Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany
[17] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
[18] Forschungszentrum Juelich GmbH, Nucl Chem INM 5, Inst Neurosci & Med, Julich, Germany
[19] Univ Clin Cologne, Inst Radiochem & Expt Mol Imaging, Cologne, Germany
[20] Life Mol Imaging GmbH, Berlin, Germany
[21] Ludwig Maximilians Univ Munchen, Ctr Neuropathol & Prion Res, Univ Hosp Munich, Munich, Germany
[22] Tech Univ Munich, Dept Neurol, Munich, Germany
[23] Hannover Med Sch, Dept Neurol, Hannover, Germany
[24] Munich Cluster Syst Neurol SyNergy, Munich, Germany
[25] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia
[26] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia
[27] Univ Melbourne, Dept Med, Austin Hlth, Melbourne, Vic, Australia
基金
欧盟地平线“2020”;
关键词
Tau; PET; F-18]PI-2620; Perfusion; Neuronal injury; POSITRON-EMISSION-TOMOGRAPHY; REFERENCE TISSUE MODEL; IMAGES;
D O I
10.1007/s00259-020-04788-w
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several beta-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [F-18]PI-2620 as a potential substitute for [F-18]fluorodeoxyglucose ([F-18]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [F-18]PI-2620 tau-PET (0-60 min p.i.) and static [F-18]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R-1) of [F-18]PI-2620-PET were correlated with corresponding quantification of [F-18]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [F-18]PI-2620 tau-PET and [F-18]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [F-18]FDG-PET quantification was reached for [F-18]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R-1) displayed strong agreement in all cortical target regions for global mean (R-SUVr 0.76, R-R1 = 0.77) and cerebellar normalization (R-SUVr 0.68, R-R1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [F-18]FDG-PET. There were no relevant differences between more and less experienced readers. Conclusion Early-phase imaging of [F-18]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [F-18]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
引用
收藏
页码:2911 / 2922
页数:12
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