Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

被引：41

作者：

Beyer, Leonie ^{[1
]}

Nitschmann, Alexander ^{[1
]}

Barthel, Henryk ^{[2
]}

van Eimeren, Thilo ^{[3
,4
,5
,6
,7
]}

Unterrainer, Marcus ^{[1
]}

Sauerbeck, Julia ^{[1
]}

Marek, Ken ^{[8
,9
]}

Song, Mengmeng ^{[1
]}

Palleis, Carla ^{[10
]}

Respondek, Gesine ^{[10
,11
]}

Hammes, Jochen ^{[4
]}

Barbe, Michael T. ^{[5
,6
]}

Onur, Oezguer ^{[5
,6
]}

Jessen, Frank ^{[7
,12
,13
]}

Saur, Dorothee ^{[14
]}

Schroeter, Matthias L. ^{[15
,16
,17
]}

Rumpf, Jost-Julian ^{[13
]}

Rullmann, Michael ^{[2
]}

Schildan, Andreas ^{[2
]}

Patt, Marianne ^{[2
]}

Neumaier, Bernd ^{[18
,19
]}

Barret, Olivier ^{[8
,9
]}

Madonia, Jennifer ^{[8
,9
]}

Russell, David S. ^{[8
,9
]}

Stephens, Andrew W. ^{[20
]}

Roeber, Sigrun ^{[21
]}

Herms, Jochen ^{[11
,21
]}

Boetzel, Kai ^{[10
]}

Levin, Johannes ^{[10
,11
]}

Classen, Joseph ^{[14
]}

Hoeglinger, Guenter U. ^{[11
,22
,23
]}

Bartenstein, Peter ^{[1
,24
]}

Villemagne, Victor ^{[25
,26
,27
]}

Drzezga, Alexander ^{[4
,7
]}

Seibyl, John ^{[8
,9
]}

Sabri, Osama ^{[2
]}

Brendel, Matthias ^{[1
,24
]}

机构：

[1] Univ Hosp Munich LMU Munich, Dept Nucl Med, Marchioninstr 15, D-81377 Munich, Germany

[2] Univ Leipzig, Dept Nucl Med, Leipzig, Germany

[3] Res Ctr Juelich, Cognit Neurosci, Inst Neurosci & Med INM 3, Julich, Germany

[4] Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany

[5] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany

[6] Univ Hosp Cologne, Cologne, Germany

[7] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[8] InviCRO LLC, Boston, MA USA

[9] InviCRO, Mol Neuroimaging, New Haven, CT USA

[10] Ludwig Maximilians Univ Munchen, Dept Neurol, Univ Hosp Munich, Munich, Germany

[11] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[12] Univ Hosp Cologne, Dept Psychiat, Cologne, Germany

[13] Univ Hosp Cologne, Ctr Memory Disorders, Cologne, Germany

[14] Univ Leipzig, Dept Neurol, Med Ctr, Leipzig, Germany

[15] Univ Leipzig, Clin Cognit Neurol, Leipzig, Germany

[16] Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany

[17] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany

[18] Forschungszentrum Juelich GmbH, Nucl Chem INM 5, Inst Neurosci & Med, Julich, Germany

[19] Univ Clin Cologne, Inst Radiochem & Expt Mol Imaging, Cologne, Germany

[20] Life Mol Imaging GmbH, Berlin, Germany

[21] Ludwig Maximilians Univ Munchen, Ctr Neuropathol & Prion Res, Univ Hosp Munich, Munich, Germany

[22] Tech Univ Munich, Dept Neurol, Munich, Germany

[23] Hannover Med Sch, Dept Neurol, Hannover, Germany

[24] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[25] Austin Hlth, Dept Mol Imaging & Therapy, Heidelberg, Vic, Australia

[26] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[27] Univ Melbourne, Dept Med, Austin Hlth, Melbourne, Vic, Australia

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2020年 / 47卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

Tau; PET; F-18]PI-2620; Perfusion; Neuronal injury; POSITRON-EMISSION-TOMOGRAPHY; REFERENCE TISSUE MODEL; IMAGES;

D O I：

10.1007/s00259-020-04788-w

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several beta-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [F-18]PI-2620 as a potential substitute for [F-18]fluorodeoxyglucose ([F-18]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson's disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [F-18]PI-2620 tau-PET (0-60 min p.i.) and static [F-18]FDG-PET (30-50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R-1) of [F-18]PI-2620-PET were correlated with corresponding quantification of [F-18]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [F-18]PI-2620 tau-PET and [F-18]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [F-18]FDG-PET quantification was reached for [F-18]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5-2.5 min SUVr & R-1) displayed strong agreement in all cortical target regions for global mean (R-SUVr 0.76, R-R1 = 0.77) and cerebellar normalization (R-SUVr 0.68, R-R1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [F-18]FDG-PET. There were no relevant differences between more and less experienced readers. Conclusion Early-phase imaging of [F-18]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [F-18]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.

引用

页码：2911 / 2922

页数：12

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