Polysaccharides in Ocular Drug Delivery

被引：115

作者：

Dubashynskaya, Natallia ^{[1
]}

Poshina, Daria ^{[1
]}

Raik, Sergei ^{[1
,2
]}

Urtti, Arto ^{[2
,3
,4
]}

Skorik, Yury A. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, Bolshoy Pr VO 31, St Petersburg 199004, Russia

[2] St Petersburg State Univ, Inst Chem, Univ Pr 26, St Petersburg 198504, Russia

[3] Univ Helsinki, Div Pharmaceut Biosci, Fac Pharm, POB 56, FI-00014 Helsinki, Finland

[4] Univ Eastern Finland, Sch Pharm, Fac Hlth Sci, Kuopio 70210, Finland

来源：

PHARMACEUTICS | 2020年 / 12卷 / 01期

关键词：

eye tissue regeneration; intravitreal administration; ocular bioavailability; ocular drug delivery; periocular administration; polysaccharide; topical administration; AQUEOUS-HUMOR PHARMACOKINETICS; DRY-EYE DISEASE; HYALURONIC-ACID; IN-VITRO; CHITOSAN NANOPARTICLES; ARTIFICIAL TEARS; HYDROXYPROPYL METHYLCELLULOSE; SUBCONJUNCTIVAL INJECTION; BIOMEDICAL APPLICATIONS; TRANSSCLERAL DELIVERY;

D O I：

10.3390/pharmaceutics12010022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.

引用

页数：30

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