Highly Regio- and Enantioselective Synthesis of γ,δ-Unsaturated Amido Esters by Catalytic Hydrogenation of Conjugated Enamides

被引：31
|
作者：
Gao, Min [1 ,2 ]
Meng, Jing-jing [1 ,2 ]
Lv, Hui [1 ,2 ]
Zhang, Xumu [1 ,2 ]
机构：
[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China
[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 06期
基金：
中国国家自然科学基金;
关键词：
amino acids; asymmetric synthesis; hydrogenation; regioselectivity; rhodium; ASYMMETRIC HYDROGENATION; AMINO-ACID; EFFICIENT SYNTHESIS; LIGANDS;
D O I：
10.1002/anie.201410213
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and highly regio- and enantioselective catalytic asymmetric hydrogenation of ,-dienamido esters to ,-unsaturated amido esters has been achieved using Rh/TangPhos as the catalyst. A series of ,-unsaturated amido acids were furnished in excellent yields with up to 99% ee. This effective methodology was applied in the asymmetric synthesis of key intermediate of Ramipril, an ACE inhibitor.
引用
收藏
页码：1885 / 1887
页数：3
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