The content of tocopherol and lipid peroxidation products in the tissues of rats with genetically determined hyperproduction of free oxygen radicals

被引：0

作者：

Kolosova, NG

Soloveva, NA

Shabalina, IG

Salganik, RI

机构：

[1] RUSSIAN ACAD MED SCI,SIBERIAN DIV,INST BIOCHEM,MOSCOW 109801,RUSSIA

[2] RUSSIAN ACAD MED SCI,SIBERIAN DIV,INST REG PATHOL & PATHOMORPHOL,MOSCOW 109801,RUSSIA

[3] RUSSIAN ACAD SCI,SIBERIAN DIV,INST CYTOL & GENET,NOVOSIBIRSK,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1996年 / 121卷 / 03期

关键词：

S rats; free oxygen radicals; tocopherol; lipid peroxidation;

D O I：

10.1007/BF02446763

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is shown that at the age of 2-3 months S rats with genetically determined hyperproduction of free radicals have the same content of tocopherol in the heart, epididymal fat, adrenals, liver, and liver mitochondria as Wistar rats but a lower content of plasma tocopherol. At 10-12 months, the tocopherol content in all studied tissues and organs, except the liver, is higher than in young S rats and age-matched Wistar rats. This is regarded as a compensatory response facilitating the stabilization of LPO under conditions of increased free radical formation.

引用

页码：259 / 261

页数：3

共 11 条

[1]

DILLARD CJ, 1984, METHOD ENZYMOL, V105, P337

[2]

KAGAN VE, 1986, ITOGI NAUKI TEKHNI B, V18

[3]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[4]

PARANICH AV, 1986, FIZIOL ZH SSSR, V32, P303