Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies

被引：1

作者：

Testa, Ugo ^{[1
]}

Castelli, Germana ^{[1
]}

Pelosi, Elvira ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Oncol, Viale Regina Elena 299, I-00161 Rome, Italy

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2022年 / 14卷

关键词：

Hematopoiesis; Hematopoietic stem cells; Clonal hematopoiesis; Gene mutations; Next generation sequencing; ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; SOMATIC MUTATIONS; DNA-DAMAGE; TP53; MUTATIONS; HUMAN PLACENTA; BONE-MARROW; CORD BLOOD; DONOR CHARACTERISTICS; PRELEUKEMIC CLONES;

D O I：

10.4084/MJHID.2022.069

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of clonal hematopoiesis. Clonal hematopoiesis of indeterminate potential (CHIP) defines the clonal expansion of genetically variant hematopoietic cells bearing one or more gene mutations and/or structural variants (such as copy number alterations). CHIP increases exponentially with age and is associated with cancers, including hematologic neoplasia, cardiovascular and other diseases. The presence of CHIP consistently increases the risk of hematologic malignancy, particularly in individuals who have CHIP in association with peripheral blood cytopenia.

引用

页数：38

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