Recent Advances of Poly(lactic-co-glycolic acid)-Based Nanoparticles for Tumor-Targeted Drug Delivery

被引：1
作者：
Jiang, Linye [1 ]
Luo, Jie [1 ]
Hong, Dawei [1 ]
Guo, Shuhong [1 ]
Wang, Shuyi [1 ]
Zhou, Bizhong [1 ]
Zhou, Shiyu [1 ]
Ge, Jingyan [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Key Lab Bioorgan Synth Zhejiang Prov, Hangzhou 310014, Peoples R China
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 03期
基金：
中国国家自然科学基金;
关键词：
PLGA; nanoparticles; surface modification; tumor targeting; drug delivery; PLGA-BASED NANOPARTICLES; HYALURONIC-ACID; IN-VITRO; BIODEGRADABLE NANOPARTICLES; POLYMERIC NANOPARTICLES; COATED NANOPARTICLES; ANTITUMOR-ACTIVITY; PACLITAXEL; CHEMOTHERAPY; NANOMATERIALS;
D O I：
10.1002/slct.202103524
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer for its biocompatibility and biodegradability. PLGA-based nanoparticles (NPs) are well recognized as promising candidates for drug delivery. However, the lack of selectivity to cancer cells limits the clinical application of PLGA-based NPs. In recent years, a number of studies were focused on tackling this limitation and showed great potential in improving the anticancer efficacy. Herein, we summarize passive tumor-targeting strategies through the EPR effect and active tumor-targeting strategies through ligand modifications based on PLGA NPs for tumor-targeted drug delivery. Finally, new challenges and possible opportunities for further research are also discussed.
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页数：11
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共 84 条
  • [1] PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
    Acharya, Sarbari
    Sahoo, Sanjeeb K.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2011, 63 (03) : 170 - 183
  • [2] [Anonymous], 2021, ANGEW CHEM-GER EDIT, V133, P2
  • [3] Targeted drug delivery to tumors: Myths, reality and possibility
    Bae, You Han
    Park, Kinam
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) : 198 - 205
  • [4] Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics
    Bertrand, Nicolas
    Grenier, Philippe
    Mahmoudi, Morteza
    Lima, Eliana M.
    Appel, Eric A.
    Dormont, Flavio
    Lim, Jong-Min
    Karnik, Rohit
    Langer, Robert
    Farokhzad, Omid C.
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [5] Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer
    Bowerman, Charles J.
    Byrne, James D.
    Chu, Kevin S.
    Schorzman, Allison N.
    Keeler, Amanda W.
    Sherwood, Candice A.
    Perry, Jillian L.
    Luft, James C.
    Darr, David B.
    Deal, Allison M.
    Napier, Mary E.
    Zamboni, William C.
    Sharpless, Norman E.
    Perou, Charles M.
    DeSimone, Joseph M.
    [J]. NANO LETTERS, 2017, 17 (01) : 242 - 248
  • [6] Hyaluronan-Inorganic Nanohybrid Materials for Biomedical Applications
    Cai, Zhixiang
    Zhang, Hongbin
    Wei, Yue
    Gong, Fengsong
    [J]. BIOMACROMOLECULES, 2017, 18 (06) : 1677 - 1696
  • [7] Development of biodegradable PLGA nanoparticles surface engineered with hyaluronic acid for targeted delivery of paclitaxel to triple negative breast cancer cells
    Cerqueira, Brenda Brenner S.
    Lasham, Annette
    Shelling, Andrew N.
    Al-Kassas, Raida
    [J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 76 : 593 - 600
  • [8] Cell membrane-coated nanoparticles for tumor-targeted drug delivery
    Chai, Zhilan
    Hu, Xuefeng
    Lu, Weiyue
    [J]. SCIENCE CHINA-MATERIALS, 2017, 60 (06) : 504 - 510
  • [9] Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin
    Chen, Hongli
    Xie, Li Qin
    Qin, Jingwen
    Jia, Yajing
    Cai, Xinhua
    Nan, WenBin
    Yang, Wancai
    Lv, Feng
    Zhang, Qi Qing
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 138 : 1 - 9
  • [10] Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer
    Chen, Shih-Hong
    Liu, Te-, I
    Chuang, Cheng-Lin
    Chen, Hsin-Hung
    Chiang, Wen-Hsuan
    Chiu, Hsin-Cheng
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (17) : 3789 - 3800
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