Recent Advances of Poly(lactic-co-glycolic acid)-Based Nanoparticles for Tumor-Targeted Drug Delivery

被引：2

作者：

Jiang, Linye ^{[1
]}

Luo, Jie ^{[1
]}

Hong, Dawei ^{[1
]}

Guo, Shuhong ^{[1
]}

Wang, Shuyi ^{[1
]}

Zhou, Bizhong ^{[1
]}

Zhou, Shiyu ^{[1
]}

Ge, Jingyan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Key Lab Bioorgan Synth Zhejiang Prov, Hangzhou 310014, Peoples R China

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PLGA; nanoparticles; surface modification; tumor targeting; drug delivery; PLGA-BASED NANOPARTICLES; HYALURONIC-ACID; IN-VITRO; BIODEGRADABLE NANOPARTICLES; POLYMERIC NANOPARTICLES; COATED NANOPARTICLES; ANTITUMOR-ACTIVITY; PACLITAXEL; CHEMOTHERAPY; NANOMATERIALS;

D O I：

10.1002/slct.202103524

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved polymer for its biocompatibility and biodegradability. PLGA-based nanoparticles (NPs) are well recognized as promising candidates for drug delivery. However, the lack of selectivity to cancer cells limits the clinical application of PLGA-based NPs. In recent years, a number of studies were focused on tackling this limitation and showed great potential in improving the anticancer efficacy. Herein, we summarize passive tumor-targeting strategies through the EPR effect and active tumor-targeting strategies through ligand modifications based on PLGA NPs for tumor-targeted drug delivery. Finally, new challenges and possible opportunities for further research are also discussed.

引用

页数：11

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