Functional significance of the platelet immune receptors GPVI and CLEC-2

被引：246

作者：

Rayes, Julie ^{[1
]}

Watson, Steve P. ^{[1
,2
,3
]}

Nieswandt, Bernhard ^{[4
,5
]}

机构：

[1] Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci, IBR Bldg, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Ctr Membrane Prot & Receptors COMPARE, Birmingham, W Midlands, England

[3] Univ Nottingham, Ctr Membrane Prot & Receptors COMPARE, Nottingham, England

[4] Univ Wurzburg, Univ Hosp, Inst Expt Biomed, Josef Schneider Str 2, D-97080 Wurzburg, Germany

[5] Univ Wurzburg, Rudolf Virchow Ctr, Josef Schneider Str 2, D-97080 Wurzburg, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

GLYCOPROTEIN VI GPVI; SEVERELY COMPROMISES HEMOSTASIS; PNEUMONIA-DERIVED SEPSIS; DEEP-VEIN THROMBOSIS; IN-VIVO; ARTERIAL THROMBOSIS; LYMPHATIC VASCULATURE; EXTRACELLULAR DOMAIN; ACTIVATED PLATELETS; PODOPLANIN PDPN;

D O I：

10.1172/JCI122955

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. CLEC-2 is activated by the transmembrane protein podoplanin, which is found outside of the vasculature and is upregulated in development, inflammation, and cancer, but there is also evidence for additional ligands. In this Review, we discuss the physiological and pathological roles of CLEC-2 and GPVI and their potential as targets in thrombosis and thromboinflammatory disorders (i.e., disorders in which inflammation plays a critical role in the ensuing thrombosis) relative to current antiplatelet drugs.

引用

页码：12 / 23

页数：12

共 172 条

[1] Antitumor effect of novel anti-podoplanin antibody NZ-12 against malignant pleural mesothelioma in an orthotopic xenograft model [J].

Abe, Shinji ;

Kaneko, Mika Kato ;

Tsuchihashi, Yuki ;

Izumi, Toshihiro ;

Ogasawara, Satoshi ;

Okada, Naoto ;

Sato, Chiemi ;

Tobiume, Makoto ;

Otsuka, Kenji ;

Miyamoto, Licht ;

Tsuchiya, Koichiro ;

Kawazoe, Kazuyoshi ;

Kato, Yukinari ;

Nishioka, Yasuhiko .

CANCER SCIENCE, 2016, 107 (09) :1198-1205

[2] Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk [J].

Abtahian, F ;

Guerriero, A ;

Sebzda, E ;

Lu, MM ;

Zhou, R ;

Mocsai, A ;

Myers, EE ;

Huang, B ;

Jackson, DG ;

Ferrari, VA ;

Tybulewicz, V ;

Lowell, CA ;

Lepore, JJ ;

Koretzky, GA ;

Kahn, ML .

SCIENCE, 2003, 299 (5604) :247-251

[3] Dendritic cells control fibroblastic reticular network tension and lymph node expansion [J].

Acton, Sophie E. ;

Farrugia, Aaron J. ;

Astarita, Jillian L. ;

Mourao-Sa, Diego ;

Jenkins, Robert P. ;

Nye, Emma ;

Hooper, Steven ;

van Blijswijk, Janneke ;

Rogers, Neil C. ;

Snelgrove, Kathryn J. ;

Rosewell, Ian ;

Moita, Luis F. ;

Stamp, Gordon ;

Turley, Shannon J. ;

Sahai, Erik ;

Reis e Sousa, Caetano .

NATURE, 2014, 514 (7523) :498-+

[4] PDGF upregulates CLEC-2 to induce T regulatory cells [J].

Agrawal, Sudhanshu ;

Ganguly, Sreerupa ;

Hajian, Pega ;

Cao, Jia-Ning ;

Agrawal, Anshu .

ONCOTARGET, 2015, 6 (30) :28621-28632

[5] Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke [J].

Al-Tamimi, Mohammad ;

Gardiner, Elizabeth E. ;

Thom, Jim Y. ;

Shen, Yang ;

Cooper, Matthew N. ;

Hankey, Graeme J. ;

Berndt, Michael C. ;

Baker, Ross I. ;

Andrews, Robert K. .

STROKE, 2011, 42 (02) :498-500

[6] Fibrin activates GPVI in human and mouse platelets [J].

Alshehri, Osama M. ;

Hughes, Craig E. ;

Montague, Samantha ;

Watson, Stephanie K. ;

Frampton, Jon ;

Bender, Markus ;

Watson, Steve P. .

BLOOD, 2015, 126 (13) :1601-1608

[7] Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands [J].

Alshehri, Osama M. ;

Montague, Samantha ;

Watson, Stephanie ;

Carter, Paul ;

Sarker, Najiat ;

Manne, Bhanu K. ;

Miller, Jeanette L. C. ;

Herr, Andrew B. ;

Pollitt, Alice Y. ;

O'Callaghan, Chris A. ;

Kunapuli, Satya ;

Arman, Monica ;

Hughes, Craig E. ;

Watson, Steve P. .

BIOCHEMICAL JOURNAL, 2015, 468 :459-473

[8] Critical role for Syk in responses to vascular injury [J].

Andre, Patrick ;

Morooka, Toshifumi ;

Sim, Derek ;

Abe, Keith ;

Lowell, Clifford ;

Nanda, Nisha ;

Delaney, Suzanne ;

Siu, Gail ;

Yan, Yibing ;

Hollenbach, Stan ;

Pandey, Anjali ;

Gao, Huiyun ;

Wang, Yunmei ;

Nakajima, Kohsuke ;

Parikh, Sahil A. ;

Shi, Can ;

Phillips, David ;

Owen, Whyte ;

Sinha, Uma ;

Simon, Daniel I. .

BLOOD, 2011, 118 (18) :5000-5010

[9] Platelet glycoprotein VI-related clinical defects [J].

Arthur, Jane F. ;

Dunkley, Scott ;

Andrews, Robert K. .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 139 (03) :363-372

[10] Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice [J].

Asai, Jun ;

Hirakawa, Satoshi ;

Sakabe, Jun-ichi ;

Kishida, Tsunao ;

Wada, Makoto ;

Nakamura, Naomi ;

Takenaka, Hideya ;

Mazda, Osam ;

Urano, Tetsumei ;

Suzuki-Inoue, Katsue ;

Tokura, Yoshiki ;

Katoh, Norito .

AMERICAN JOURNAL OF PATHOLOGY, 2016, 186 (01) :101-108

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