Synthesis and characterization of multimeric salicylaldimine thiosemicarbazones and their Pd(II) and Pt(II) complexes

被引：18

作者：

Stringer, Tameryn ^{[1
]}

Hendricks, Denver T. ^{[2
]}

Guzgay, Hajira ^{[2
]}

Smith, Gregory S. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa

[2] Univ Cape Town, Div Med Biochem, ZA-7701 Cape Town, South Africa

来源：

POLYHEDRON | 2012年 / 31卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Salicylaldimine; Multimeric thiosemicarbazones; Palladium; Platinum; TRANSITION-METAL COMPLEXES; PALLADIUM(II) COMPLEXES; CRYSTAL-STRUCTURE; SPECTRAL PROPERTIES; 1,3,5-TRIAZA-7-PHOSPHAADAMANTANE PTA; 2-ACETYLPYRIDINE THIOSEMICARBAZONE; SPECTROSCOPIC PROPERTIES; PLATINUM(II) COMPLEXES; CYTOTOXIC ACTIVITY; ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.poly.2011.10.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of di- and trithiosemicarbazone ligands as well as their Pd(II) and Pt(II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes have been synthesised using templated reactions between various substituted salicylaldimine thiosemicarbazone ligands and metal precursors of the general formula cis-[M(PTA)(2)Cl-2], where M = Pd or Pt. Characterization of these complexes was achieved using various analytical and spectroscopic techniques: elemental analysis, ESI-MS, FT-IR, and NMR (H-1, C-13{H-1) and P-31{H-1}) spectroscopy. The data revealed tridentate (O-N-S) coordination of the thiosemicarbazone moieties via the imine nitrogen, thiolato sulfur and phenolic oxygen to each metal center. in vitro biological evaluation of selected compounds was conducted against WHCO1 oesophageal cancer cells. Some of the multimeric compounds display some promising biological activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

收藏

页码：486 / 493

页数：8

相关论文

共 39 条

[1] Control of tumour vascular permeability [J].

Baban, DF ;

Seymour, LW .

ADVANCED DRUG DELIVERY REVIEWS, 1998, 34 (01) :109-119

[2] TRANSITION-METAL COMPLEXES OF THIOSEMICARBAZIDE AND THIOSEMICARBAZONES [J].

CAMPBELL, MJM .

COORDINATION CHEMISTRY REVIEWS, 1975, 15 (2-3) :279-319

[3] Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis [J].

Chellan, Prinessa ;

Stringer, Tameryn ;

Shokar, Ajit ;

Dornbush, Padraick J. ;

Vazquez-Anaya, Guillermo ;

Land, Kirkwood M. ;

Chibale, Kelly ;

Smith, Gregory S. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (12) :1562-1568

[4] Synthesis, Structure and in Vitro Biological Screening of Palladium(II) Complexes of Functionalised Salicylaldimine Thiosemicarbazones as Antimalarial and Anticancer Agents [J].

Chellan, Prinessa ;

Shunmoogam-Gounden, Nelusha ;

Hendricks, Denver T. ;

Gut, Jiri ;

Rosenthal, Philip J. ;

Lategan, Carmen ;

Smith, Peter J. ;

Chibale, Kelly ;

Smith, Gregory S. .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2010, (22) :3520-3528

[5] The exocyclic functionalisation of bis(thiosemicarbazonate) complexes of zinc and copper: the synthesis of monomeric and dimeric species [J].

Christlieb, Martin ;

Struthers, Harriet S. R. ;

Bonnitcha, Paul D. ;

Cowley, Andrew R. ;

Dilworth, Jonathan R. .

DALTON TRANSACTIONS, 2007, (43) :5043-5054

[6] INHIBITORS OF RIBONUCLEOTIDE REDUCTASE - COMPARATIVE EFFECTS OF AMINO-SUBSTITUTED AND HYDROXY-SUBSTITUTED PYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONES [J].

CORY, JG ;

CORY, AH ;

RAPPA, G ;

LORICO, A ;

LIU, MC ;

LIN, TS ;

SARTORELLI, AC .

BIOCHEMICAL PHARMACOLOGY, 1994, 48 (02) :335-344

[7] An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: Implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives [J].

Cowley, AR ;

Dilworth, JR ;

Donnelly, PS ;

Labisbal, E ;

Sousa, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (19) :5270-5271

[8] Water-soluble organometallic compounds .6. Synthesis, spectral properties, and crystal structures of complexes of 1,3,5-triaza-7-phosphaadamantane with group 10 metals [J].

Darensbourg, DJ ;

Decuir, TJ ;

Stafford, NW ;

Robertson, JB ;

Draper, JD ;

Reibenspies, JH .

INORGANIC CHEMISTRY, 1997, 36 (19) :4218-4226

[9] Self-aggregation behaviour of novel thiosemicarbazone drug candidates with potential antiviral activity [J].

Glisoni, Romina J. ;

Chiappetta, Diego A. ;

Finkielsztein, Liliana M. ;

Moglioni, Albertina G. ;

Sosnik, Alejandro .

NEW JOURNAL OF CHEMISTRY, 2010, 34 (09) :2047-2058

[10] METAL-COMPOUNDS IN CANCER-CHEMOTHERAPY [J].

HAIDUC, I ;

SILVESTRU, C .

COORDINATION CHEMISTRY REVIEWS, 1990, 99 :253-296

← 1 2 3 4 →