A radiation hybrid map of the rat genome containing 5,255 markers

被引：212

作者：

Watanabe, TK

Bihoreau, MT

McCarthy, LC

Kiguwa, SL

Hishigaki, H

Tsuji, A

Browne, J

Yamasaki, Y

Mizoguchi-Miyakita, A

Oga, K

Ono, T

Okuno, S

Kanemoto, N

Takahashi, E

Tomita, K

Hayashi, H

Adachi, M

Webber, C

Davis, M

Kiel, S

Knights, C

Smith, A

Critcher, R

Miller, J

Thangarajah, T

Day, PJR

Hudson, JR

Irie, Y

Takagi, T

Nakamura, Y

Goodfellow, PN

Lathrop, GM

Tanigami, A

James, MR

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Tokushima 7710192, Japan

[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[4] Res Genet Inc, Huntsville, AL 35801 USA

[5] Univ Tokyo, Inst Med Sci, Mol Med Lab, Minato Ku, Tokyo 108, Japan

来源：

NATURE GENETICS | 1999年 / 22卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/8737

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A whole-genome radiation hybrid (RH) panel was used to construct a high-resolution map of the rat genome based on microsatellite and gene markers. These include 3,019 new microsatellite markers described here for the first time and 1,714 microsatellite markers with known genetic locations, allowing comparison and integration of maps from different sources. A robust RH framework map containing 1,030 positions ordered with odds of at least 1,000:1 has been defined as a tool for mapping these markers, and for future RH mapping in the rat, More than 500 genes which have been mapped in mouse and/or human were localized with respect to the rat RH framework, allowing the construction of detailed rat-mouse and rat-human comparative maps and illustrating the power of the RH approach for comparative mapping.

引用

页码：27 / 36

页数：10

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