Lipid Nanoparticles for the Delivery of Active Natural Medicines

被引:17
作者
Xing, Huijie [1 ,2 ]
Wang, Huan [1 ]
Wu, Baojian [1 ]
Zhang, Xingwang [1 ]
机构
[1] Jinan Univ, Div Pharmaceut, Coll Pharm, 601 West Huangpu Ave, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Inst Lab Anim, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; drug delivery; natural medicines; bioactive compounds; OCULAR DRUG-DELIVERY; IN-VIVO EVALUATION; ACUTE MYOCARDIAL-ISCHEMIA; OF-THE-ART; ORAL DELIVERY; CELLULAR UPTAKE; CANCER-THERAPY; TRANSDERMAL DELIVERY; OPHTHALMIC DELIVERY; ANTITUMOR-ACTIVITY;
D O I
10.2174/1381612824666171128105853
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Thousands of bioactive compounds are identified and isolated from the medicinal plants every year, of which many possess significant health benefits. However, the overwhelming majority of entities suffer from poor water solubility and membrane permeability that impedes them approaching the clinical stage. Methods: Lipid nanoparticles have shown to be a versatile platform for advanced delivery of various therapeuticals, including the oral, topical and systemic routes. Lipid nanoparticles are able to significantly improve the oral bioavailability, pharmacokinetic profile, skin permeability, and ocular residence time of drugs, demonstrating considerable potential in pharmaceutical or medical practice. Results: This article profoundly reviews important applications of lipid nanoparticles in active natural medicines. Special concerns focus on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for their training in the oral, intravenous, percutaneous and ocular drug delivery. Conclusion: The survey shows that lipid nanoparticles are promising vehicles for the delivery of various natural actives and may address some intractable problems associated with delivery thereof.
引用
收藏
页码:6705 / 6713
页数:9
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