Submicron-textured biomaterial surface reduces staphylococcal bacterial adhesion and biofilm formation

被引:138
作者
Xu, Li-Chong
Siedlecki, Christopher A. [1 ,2 ]
机构
[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Surg, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Inst Biomed Engn, Hershey, PA 17033 USA
关键词
Textured biomaterials; Bacterial adhesion; Biofilm formation; Staphylococci; Polyurethane; COAGULASE-NEGATIVE STAPHYLOCOCCI; CARE-ASSOCIATED INFECTIONS; DEVICE-RELATED INFECTIONS; FIBROBLAST RESPONSE; PLATELET-ADHESION; IMPLANT MATERIALS; BLOOD-CONTACT; AUREUS; EPIDERMIDIS; ATTACHMENT;
D O I
10.1016/j.actbio.2011.08.009
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Staphylococci are among the most important pathogens causing bloodstream infections associated with implanted medical devices. Control of bacterial adhesion to material surfaces is important for prevention of biofilm formation and biomaterial-associated infections. In this study, we hypothesized that submicron (staphylococcal bacterial dimension) surface textures may reduce the bacterial adhesion via a decrease in surface area that bacteria can contact, and subsequently inhibit biofilm formation. Poly(urethane urea) films were textured with two different sizes of submicron pillars via a two-stage replication process. Adhesion of two bacterial strains (Staphylococcus epidermidis RP62A and S. aureus Newman) was assessed over a shear stress range of 0-13.2 dyn cm(-2) using a rotating disk system in physiological buffer solutions. Significant decreases in bacterial adhesion were observed on textured surfaces for both strains compared with smooth controls. Biofilm formation was further tested on surfaces incubated in solution for either 2 or 5 days and it was found that biofilm formation was dramatically inhibited on textured surfaces. The results of the approaches used in this work demonstrate that patterned surface texturing of biomaterials provides an effective means to reduce staphylococcal adhesion and biofilm formation on biomaterial surfaces, and thus to prevent biomaterial-associated infections. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:72 / 81
页数:10
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