Lipoprotein-associated phospholipase A2 (Lp-PLA2): a review of its role and significance as a cardiovascular biomarker

被引：49
作者：
Vittos, Oana [1 ,2 ]
Toana, Bogdan [3 ]
Vittos, Alexandros [1 ]
Moldoveanu, Elena [4 ,5 ]
机构：
[1] Medctr, Bucharest, Romania
[2] Univ Med & Pharm Carol Davila, Bucharest, Romania
[3] Dr Carol Davila Clin Cent Mil Emergency Hosp, Bucharest, Romania
[4] Victor Babes Natl Inst Pathol, Bucharest, Romania
[5] Titu Maiorescu Univ, Fac Med, Bucharest, Romania
来源：
BIOMARKERS | 2012年 / 17卷 / 04期
关键词：
Cardiovascular disease; growth factors/cytokines/inflammatory mediators; oxidative stress; PLATELET-ACTIVATING-FACTOR; FACTOR-ACETYLHYDROLASE ACTIVITY; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; RISK-FACTORS; ARTERY-DISEASE; INDEPENDENT PREDICTOR; ISCHEMIC-STROKE; ATHEROSCLEROTIC PLAQUE;
D O I：
10.3109/1354750X.2012.664170
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To conduct a comprehensive, systematic review of studies assessing the significance of lipoproteinassociated phospholipase A2 in cardiovascular diseases (CVDs). Material and methods: A review of the literature was performed using the search term "Lipoprotein-associated phospholipase A2 (Lp-PLA2)" and each of the following terms: "cardiovascular risk," "cardiovascular death," " atherosclerotic disease," "coronary events," "transient ischemic attack (TIA)," "stroke," and "heart failure." The searches were performed on Medline, Google Scholar and ClinicalTrails. gov. Results: The majority of published studies showed a significant association between Lp-PLA2 levels and cardiovascular events after multivariate adjustment. The association was consistent across a wide variety of subjects of both sexes and different ethnic backgrounds. Conclusions: The role of Lp-PLA2 as a significant biomarker of vascular inflammation was confirmed, and Lp-PLA2 seems to be closely correlated to cardiovascular events. It may be an important therapeutic target and may have an important role in prevention, risk stratification and personalised medicine.
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收藏
页码：289 / 302
页数：14
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