The unmasking of novel unipotent stem cells in the mammary gland

被引：14
作者：
Visvader, Jane E. [1 ,2 ]
Lindeman, Geoffrey J. [1 ,3 ,4 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Stem Cells & Canc Div, Melbourne, Vic 3050, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia
[3] Royal Melbourne Hosp, Dept Med Oncol, Melbourne, Vic, Australia
[4] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
来源：
EMBO JOURNAL | 2011年 / 30卷 / 24期
关键词：
EPITHELIAL-CELLS; EXPRESSION;
D O I：
10.1038/emboj.2011.415
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammary stem cells (MaSCs) have been prospectively isolated and shown to reconstitute a fully functional mammary gland in the mouse at the single cell level. These cells are self-renewing and can differentiate into all mature mammary epithelial cell types, thus fulfilling the defining characteristics of a stem cell. In a recent issue of Nature, Blanpain and colleagues (Van Keymeulen et al, 2011) add a new layer of complexity to the prevailing model of the mammary epithelial hierarchy through the recognition of novel unipotent stem cells that appear to maintain normal homeostasis of postnatal mammary epithelium. These data point to the existence of an unexpectedly complex hierarchy of stem cells that include multipotent as well as more restricted stem cells.
引用
收藏
页码：4858 / 4859
页数：2
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