Co-regulation of constitutive nitric oxide synthases and NADPH oxidase by the small GTPase Rac

被引:38
|
作者
Selvakumar, Balakrishnan [2 ]
Hess, Douglas T. [1 ]
Goldschmidt-Clermont, Pascal J. [1 ]
Stamler, Jonathan S. [1 ,3 ]
机构
[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA
关键词
nitric oxide; nitric oxide synthase; NADPH oxidase; Rac; small GTPase;
D O I
10.1016/j.febslet.2008.04.062
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nitric oxide (NO), generated by NO synthases (NOSs), has multifarious roles in signal transduction. Reactive oxygen species (ROS), generated by ubiquitous NADPH oxidases (NOXs), also participate in cellular signaling. However, the coordination of signals conveyed by NO and ROS is poorly understood. We show that the small GTPase Rac, a component of some NOXs, also interacts with and regulates the constitutively-ex pressed NOSs. Cellular NO and O-2(-) production increase or decrease together following activation or inhibition of Rac, and Rac inhibition reveals transduction mechanisms that depend upon NO (vasodilation), ROS (actin polymerization) or both (cytoskeletal organization). Thus, signaling by NO and ROS may be coordinated through a common control element. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:2195 / 2202
页数:8
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