Novel biphenol phosphoramidite ligands for the enantioselective copper catalyzed conjugate addition of dialkyl zincs

被引：1
作者：
Alexakis, A [1 ]
Rosset, S [1 ]
Allamand, J [1 ]
March, S [1 ]
Guillen, F [1 ]
Benhaim, C [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
SYNLETT | 2001年 / 09期
关键词：
asymmetric catalysis; copper; zinc; Michael additions; phosphorus; atropoisomerism;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.
引用
收藏
页码：1375 / 1378
页数：4
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