Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification

被引：53
作者：
Teixeira, Cristina C. [1 ]
Agoston, Hanga [2 ]
Beier, Frank [2 ]
机构：
[1] NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, New York, NY 10010 USA
[2] Univ Western Ontario, Dept Physiol & Pharmacol, CIHR Grp Skeletal Dev Remodeling, London, ON, Canada
来源：
DEVELOPMENTAL BIOLOGY | 2008年 / 319卷 / 02期
关键词：
nitric oxide; C-type natriuretic peptide; cGMP; cGMP-dependent kinase; cartilage; endochondralbone; MAPK pathways;
D O I：
10.1016/j.ydbio.2008.04.031
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：171 / 178
页数：8
相关论文
共 100 条
  • [61] Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification
    Miyazawa, T
    Ogawa, Y
    Chusho, H
    Yasoda, A
    Tamura, N
    Komatsu, Y
    Pfeifer, A
    Hofmann, F
    Nakao, K
    [J]. ENDOCRINOLOGY, 2002, 143 (09) : 3604 - 3610
  • [62] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms
    Morishita, T
    Tsutsui, M
    Shimokawa, H
    Sabanai, K
    Tasaki, H
    Suda, O
    Nakata, S
    Tanimoto, A
    Wang, KY
    Ueta, Y
    Sasaguri, Y
    Nakashima, Y
    Yanagihara, N
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) : 10616 - 10621
  • [63] Heterozygous mutations in natriuretic peptide receptor-B (NPR2) are associated with short stature
    Olney, RC
    Bükülmez, H
    Bartels, CF
    Prickett, TCR
    Espiner, EA
    Potter, LR
    Warman, ML
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (04) : 1229 - 1232
  • [64] Bone development
    Olsen, BR
    Reginato, AM
    Wang, WF
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 : 191 - 220
  • [65] FGF signaling in the developing endochondral skeleton
    Ornitz, DM
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (02) : 205 - 213
  • [66] INDUCTION OF NITRIC-OXIDE SYNTHASE IN HUMAN CHONDROCYTES
    PALMER, RMJ
    HICKERY, MS
    CHARLES, IG
    MONCADA, S
    BAYLISS, MT
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 193 (01) : 398 - 405
  • [67] NITRIC-OXIDE RELEASE ACCOUNTS FOR THE BIOLOGICAL-ACTIVITY OF ENDOTHELIUM-DERIVED RELAXING FACTOR
    PALMER, RMJ
    FERRIGE, AG
    MONCADA, S
    [J]. NATURE, 1987, 327 (6122) : 524 - 526
  • [68] Peunova N, 1998, NITRIC OXIDE AND THE CELL, P171
  • [69] Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II
    Pfeifer, A
    Aszodi, A
    Seidler, U
    Ruth, P
    Hofmann, F
    Fassler, R
    [J]. SCIENCE, 1996, 274 (5295) : 2082 - 2086
  • [70] Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
    Potter, LR
    Abbey-Hosch, S
    Dickey, DM
    [J]. ENDOCRINE REVIEWS, 2006, 27 (01) : 47 - 72
12345678910