Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification

被引：55

作者：

Teixeira, Cristina C. ^{[1
]}

Agoston, Hanga ^{[2
]}

Beier, Frank ^{[2
]}

机构：

[1] NYU, Coll Dent, Dept Basic Sci & Craniofacial Biol, New York, NY 10010 USA

[2] Univ Western Ontario, Dept Physiol & Pharmacol, CIHR Grp Skeletal Dev Remodeling, London, ON, Canada

来源：

DEVELOPMENTAL BIOLOGY | 2008年 / 319卷 / 02期

关键词：

nitric oxide; C-type natriuretic peptide; cGMP; cGMP-dependent kinase; cartilage; endochondralbone; MAPK pathways;

D O I：

10.1016/j.ydbio.2008.04.031

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：171 / 178

页数：8

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