Hollow Nanospheres Based on the Self-Assembly of Alginate-graft-poly(ethylene glycol) and α-Cyclodextrin

被引：31
作者：
Meng, Xian-Wei [1 ,2 ]
Ha, Wei [1 ]
Cheng, Cong [2 ]
Dong, Zhen-Qiang [2 ]
Ding, Li-Sheng [2 ]
Li, Bang-Jing [1 ]
Zhang, Sheng [2 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu 610041, Peoples R China
[2] Sichuan Univ, State Key Lab Polymer Mat Engn, Polymer Res Inst, Chengdu 610065, Peoples R China
来源：
LANGMUIR | 2011年 / 27卷 / 23期
基金：
中国国家自然科学基金;
关键词：
COIL BLOCK-COPOLYMERS; PEG INCLUSION COMPLEX; POLY(ETHYLENE GLYCOL); COMMON SOLVENT; FREE STRATEGY; SPHERES; MICELLES; ENCAPSULATION; PARTICLES; MOLECULES;
D O I：
10.1021/la2028803
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article studies the self-assembly of alginate-graft-poly(ethylene glycol) (Alg-g-PEG) and alpha-cyclodextrin (alpha-CD) in aqueous solution. It was found that they could form hollow spheres because of the formation of coil-rod Alg-g-PEG/alpha-CD inclusion complexes. In these Alg-g-PEG/alpha-CD complexes, the alpha-CDs are stacked along the PEG side chains to form a rod block, and alginate main chains act as a coil block. More rod-like blocks in Alg-g-PEG/alpha-CD favor the formation of small assemblies. The assemblies of Alg-g-PEG/alpha-CD show a dependence on concentration, temperature, pH, and salt concentration. At low concentration (below 0.125%) or high temperature (above 32 degrees C), Alg-g-PEG/alpha-CD particles were unstable and disrupted. Increasing the salt or decreasing the pH resulted in the aggregation of Alg-g-mPEG/alpha-CD particles, as detected by the increase in the recorded hydrodynamic diameter (D-h).
引用
收藏
页码：14401 / 14407
页数：7
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