Of concern are multiplicative perturbations of the Laplacian acting on weighted spaces of continuous functions on R(N), N >= 1 . It is proved that such differential operators, defined on their maximal domains, are pre-generators of positive quasicontractive C (0)-semigroups of operators that fulfill the Feller property. Accordingly, these semigroups are associated with a suitable probability transition function and hence with a Markov process on R(N) . An approximation formula for these semigroups is also stated in terms of iterates of integral operators that generalize the classical Gauss-Weierstrass operators. Some applications of such approximation formula are finally shown concerning both the semigroups and the associated Markov processes.