The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

被引：85

作者：

Evans, James C. ^{[1
]}

Malhotra, Meenakshi ^{[1
]}

Cryan, John F. ^{[2
]}

O'Driscoll, Caitriona M. ^{[1
]}

机构：

[1] Univ Coll Cork, Sch Pharm, Pharmacodelivery Grp, Cork, Ireland

[2] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2016年 / 173卷 / 21期

关键词：

LINKED-ACIDIC DIPEPTIDASE; NAAG PEPTIDASE INHIBITORS; N-ACETYLASPARTYLGLUTAMATE NAAG; HUMAN GLUTAMATE CARBOXYPEPTIDASES; GA-68-LABELED PSMA LIGAND; ACETYL-ASPARTYL-GLUTAMATE; MONOCLONAL-ANTIBODY J591; DENDRITIC CELL VACCINE; ENZYME PRODRUG THERAPY; UREA-BASED INHIBITORS;

D O I：

10.1111/bph.13576

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prostate specific membrane antigen (PSMA) otherwise known as glutamate carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in prostate cancer and in the neovasculature of a wide variety of tumours including glioblastomas, breast and bladder cancers. This protein is also involved in a variety of neurological diseases including schizophrenia and ALS. In recent years, there has been a surge in the development of both diagnostics and therapeutics that take advantage of the expression and activity of PSMA/GCPII. These include gene therapy, immunotherapy, chemotherapy and radiotherapy. In this review, we discuss the biological roles that PSMA/GCPII plays, both in normal and diseased tissues, and the current therapies exploiting its activity that are at the preclinical stage. We conclude by giving an expert opinion on the future direction of PSMA/GCPII based therapies and diagnostics and hurdles that need to be overcome to make them effective and viable.

引用

页码：3145 / U108

页数：39

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