Voltammetric method for simultaneous determination of ascorbic acid, paracetamol and guaifenesin using a sequential experimentation strategy

被引：25

作者：

Hendawy, Hassan A. M. ^{[1
]}

Ibrahim, Ahmed M. ^{[1
]}

Hassan, Wafaa S. ^{[2
]}

Shalaby, Abdalla ^{[2
]}

El-sayed, Heba M. ^{[2
]}

机构：

[1] Natl Org Drug Control & Res, POB 29, Cairo, Egypt

[2] Zagazig Univ, Fac Pharm, Dept Analyt Chem, Zagazig, Egypt

来源：

MICROCHEMICAL JOURNAL | 2019年 / 145卷

关键词：

Dual response surface method; Fractional factorial design; Graphene oxide; Multi-walled carbon nanotubes; Square wave voltanunetry; WALLED CARBON NANOTUBES; IMPRINTED ELECTROCHEMICAL SENSOR; GRAPHENE OXIDE; SENSITIVE DETERMINATION; GOLD NANOPARTICLES; SELECTIVE DETERMINATION; QUERCETIN; ELECTRODE; ELECTROANALYSIS; PHARMACEUTICALS;

D O I：

10.1016/j.microc.2018.11.010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cold is a leading cause of school and work absenteeism. Most cold over-the-counter medicines (OTC) contain paracetamol (PA), guaifenesin (GU) and other active ingredients. Ascorbic acid (AS) in pharmaceutical preparations is designed for preventing and treating respiratory viral infections. Thus, we report a robust voltammetric method for simultaneous determination of AS, PA and GU in their effervescent dosage form. The advantages of nanotechnology and chemometrics were combined to enhance the performance of electroanalysis. Fractional factorial design (FrFD) and dual response surface method (DRSM) were sequentially conducted. The method was validated in agreement with ICH guidelines; it showed accuracy over the concentration range of 11.3-108.9, 14.6-140.3, 4.6-43.9 mu g ml(-1) for AS, PA and GU, respectively. Based on findings, a robust and not time-consuming procedure was applied.

引用

页码：428 / 434

页数：7

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