A case study of trastuzumab treatment for metastatic breast cancer in pregnancy: fetal risks and management of cerebral metastases

被引：12

作者：

Mandrawa, Christine L. ^{[1
]}

Stewart, Josephine ^{[2
]}

Fabinyi, Gavin C. ^{[3
]}

Walker, Susan P. ^{[1
]}

机构：

[1] Mercy Hosp Women, Univ Dept Obstet & Gynaecol, Heidelberg, Vic 3084, Australia

[2] Austin Hlth, Dept Med Oncol, Melbourne, Vic, Australia

[3] Austin Hlth, Dept Neurosurg, Melbourne, Vic, Australia

来源：

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | 2011年 / 51卷 / 04期

关键词：

breast neoplasm; neoplasm metastasis; oligohydramnios; pregnancy; trastuzumab; NERVOUS-SYSTEM METASTASES; SURVIVAL; SAFE;

D O I：

10.1111/j.1479-828X.2011.01314.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Trastuzumab increases survival amongst women with human epidermal growth factor receptor (HER)-2 receptor positive metastatic breast cancer, but maternal and fetal risks are associated with advanced disease and its treatment in pregnancy. We present a case of a primigravid with HER-2 positive metastatic breast cancer who received trastuzumab throughout pregnancy. She presented with cerebral metastases, requiring surgical decompression and resection. Reversible oligohydramnios developed during pregnancy. Fetal safety data on trastuzumab in pregnancy is limited, but case reports suggest a recurring pattern of (mostly reversible) oligohydramnios.

引用

页码：372 / 376

页数：5

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