Subventricular zone in motor neuron disease with frontotemporal dementia

被引：11

作者：

Galan, Lucia ^{[1
]}

Gomez-Pinedo, Ulises ^{[2
,3
,6
,8
]}

Vela-Souto, Alvaro ^{[1
]}

Guerrero-Sola, Antonio ^{[1
]}

Antonio Barcia, Juan ^{[3
]}

Rabano Gutierrez, Alberto ^{[4
,5
]}

Martinez-Martinez, Armando ^{[6
]}

Barquero Jimenez, Maria Sagrario ^{[7
]}

Manuel Garcia-Verdugo, Jose ^{[2
]}

Matias-Guiu, Jorge ^{[7
]}

机构：

[1] Hosp Clin San Carlos Calle, Dept Neurol, Neuromuscular Unit, Madrid 28040, Spain

[2] Univ Valencia, Mix Unit, CIBERNED, Ctr Invest Principe Felipe, Valencia, Spain

[3] Hosp Clin San Carlos, Dept Neurosurg, Madrid, Spain

[4] ISCIII, Fdn CIEN, Res Unit Alzheimer Proyect, Dept Pathol, Madrid, Spain

[5] ISCIII, Fdn CIEN, Res Unit Alzheimer Proyect, Brain Bank, Madrid, Spain

[6] Hosp Clin San Carlos, Dept Neurol, Madrid, Spain

[7] Hosp Clin San Carlos, Dept Pathol, Madrid, Spain

[8] Hosp Clin San Carlos, Inst Neurosci, Madrid, Spain

来源：

NEUROSCIENCE LETTERS | 2011年 / 499卷 / 01期

关键词：

Amyotrophic lateral Sclerosis; Neurogenesis; Frontotemporal lobar degeneration; Motor neuron disease; Subventricular zone; AMYOTROPHIC-LATERAL-SCLEROSIS; STEM-CELLS; INCREASED NUMBER; HUMAN BRAIN; NEUROGENESIS; HIPPOCAMPUS; NICHE;

D O I：

10.1016/j.neulet.2011.05.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：9 / 13

页数：5

共 20 条

[1] A CONTROLLED TRIAL OF RILUZOLE IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

BENSIMON, G ;

LACOMBLEZ, L ;

MEININGER, V ;

BOUCHE, P ;

DELWAIDE, C ;

COURATIER, P ;

BLIN, O ;

VIADER, F ;

PEYROSTPAUL, H ;

DAVID, J ;

MALOTEAUX, JM ;

HUGON, J ;

LATERRE, EC ;

RASCOL, A ;

CLANET, M ;

VALLAT, JM ;

DUMAS, A ;

SERRATRICE, G ;

LECHEVALLIER, B ;

PEUCH, AJ ;

NGUYEN, T ;

SHU, C ;

BASTIEN, P ;

PAPILLON, C ;

DURRLEMAN, S ;

LOUVEL, E ;

GUILLET, P ;

LEDOUX, L ;

ORVOENFRIJA, E ;

DIB, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (09) :585-591

[2] Increased number of neural progenitors in human temporal lobe epilepsy [J].

Crespel, A ;

Rigau, V ;

Coubes, P ;

Rousset, MC ;

de Bock, F ;

Okano, H ;

Baldy-Moulinier, M ;

Bockaert, J ;

Lerner-Natoli, M .

NEUROBIOLOGY OF DISEASE, 2005, 19 (03) :436-450

[3] The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain [J].

Curtis, MA ;

Penney, EB ;

Pearson, J ;

Dragunow, M ;

Connor, B ;

Faull, RLM .

NEUROSCIENCE, 2005, 132 (03) :777-788

[4] Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up [J].

Deda, H. ;

Inci, M. C. ;

Kurekci, A. E. ;

Sav, A. ;

Kayihan, K. ;

Ozgun, E. ;

Ustunsoy, G. E. ;

Kocabay, S. .

CYTOTHERAPY, 2009, 11 (01) :18-25

[5] EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells [J].

Doetsch, F ;

Petreanu, L ;

Caille, I ;

Garcia-Verdugo, JM ;

Alvarez-Buylla, A .

NEURON, 2002, 36 (06) :1021-1034

[6] Neurogenesis in the adult human hippocampus [J].

Eriksson, PS ;

Perfilieva, E ;

Björk-Eriksson, T ;

Alborn, AM ;

Nordborg, C ;

Peterson, DA ;

Gage, FH .

NATURE MEDICINE, 1998, 4 (11) :1313-1317

[7] Synaptic integration and plasticity of new neurons in the adult hippocampus [J].

Ge, Shaoyu ;

Sailor, Kurt A. ;

Ming, Guo-li ;

Song, Hongjun .

JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (16) :3759-3765

[8]

HONG XP, 2009, HIPPOCAMPUS

[9] Increased hippocampal neurogenesis in Alzheimer's disease [J].

Jin, KL ;

Peel, AL ;

Mao, XO ;

Xie, L ;

Cottrell, BA ;

Henshall, DC ;

Greenberg, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :343-347

[10] Increased number and differentiation of neural precursor cells in the brainstem of superoxide dismutase 1G93A G1H transgenic mouse model of amyotrophic lateral sclerosis [J].

Juan, Liu ;

Dawei, Zang ;

Julie, Atkin D. .

NEUROLOGICAL RESEARCH, 2007, 29 (02) :204-209

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