[1] Inst Res Biomed IBiMED & Hlth Sci, Aveiro, Portugal
[2] Univ Coimbra FFUC, Fac Pharm, P-3000 Coimbra, Portugal
[3] Univ Beira Interior CICS UBI, Hlth Sci Res Ctr, Covilha, Portugal
[4] Polytech Guarda UDI IPG, Res Unit Inland Dev, Guarda, Portugal
[5] Univ Coimbra CNC UC, Ctr Neurosci & Cell Biol, Coimbra, Portugal
[6] CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain
[7] Inst Invest & Formacao Avancada Ciencias & Tecnol, CESPU, Gandra, Portugal