LOW-MOLECULAR-WEIGHT;
HEPARIN-INDUCED THROMBOCYTOPENIA;
DEEP-VEIN THROMBOSIS;
ED AMERICAN-COLLEGE;
REPORTED TREATMENT SATISFACTION;
XA INHIBITOR RIVAROXABAN;
UNFRACTIONATED HEPARIN;
PEDIATRIC-PATIENTS;
ANTITHROMBOTIC THERAPY;
DABIGATRAN ETEXILATE;
D O I:
10.1007/s40272-020-00403-5
中图分类号:
R72 [儿科学];
学科分类号:
100202 ;
摘要:
Venous thromboembolism (VTE) is an important but historically under-recognized problem in pediatrics, with an incidence concentrated in hospitalized children. A number of specific VTE diseases with discrete triggers have been described, but the most common pediatric trigger is the presence of central venous access devices. VTE diseases, though heterogenous in etiology, are linked by the common therapeutic strategies shared by their management. Historically, the most commonly used drug therapies have been unfractionated heparin, low-molecular-weight heparins, and vitamin K antagonists, based on extrapolation from adult data rather than any specific pediatric trials. Although these widely used drugs appear safe and effective in expert hands, the historical lack of pediatric data is problematic in view of the recognized significant differences between children and adults with regards to hemostatic physiology, VTE etiology, and drug pharmacokinetics. The increasing adult usage of novel VTE pharmacotherapies such as direct oral anticoagulants (DOACs) has led to considerable interest in exploring the pediatric applications of these newer drugs. This review summarizes the advantages and disadvantages of existing VTE pharmacotherapies and outlines emerging novel pediatric VTE therapies, particularly DOACs, within the context of the current pediatric trial landscape.
机构:
Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, ItalyUniv Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Agnelli, Giancarlo
Gallus, Alexander
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Gallus, Alexander
Goldhaber, Samuel Z.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Goldhaber, Samuel Z.
Haas, Sylvia
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Haas, Sylvia
Huisman, Menno V.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Huisman, Menno V.
Hull, Russel D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Hull, Russel D.
Kakkar, Ajay K.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Kakkar, Ajay K.
Misselwitz, Frank
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Misselwitz, Frank
Schellong, Sebastian
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
机构:
Univ Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, ItalyUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Agnelli, Giancarlo
Buller, Harry R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, NetherlandsUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Buller, Harry R.
Cohen, Alexander
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, London, EnglandUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Cohen, Alexander
Curto, Madelyn
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Curto, Madelyn
Gallus, Alexander S.
论文数: 0引用数: 0
h-index: 0
机构:
Flinders Med Ctr, Dept Haematol, Adelaide, SA, Australia
Flinders Univ S Australia, Adelaide, SA 5001, AustraliaUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Gallus, Alexander S.
Johnson, Margot
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Johnson, Margot
Masiukiewicz, Urszula
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Masiukiewicz, Urszula
Pak, Raphael
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Pak, Raphael
Thompson, John
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Thompson, John
Raskob, Gary E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Raskob, Gary E.
Weitz, Jeffrey I.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Med, Hamilton, ON, Canada
McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada
Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, CanadaUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
机构:
Flinders Med Ctr, Adelaide, SA, Australia
Flinders Univ S Australia, Dept Haematol, Adelaide, SA 5001, AustraliaUniv Perugia, Dept Internal & Cardiovasc Med, Stroke Unit, I-06100 Perugia, Italy
机构:
Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, ItalyUniv Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Agnelli, Giancarlo
Gallus, Alexander
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Gallus, Alexander
Goldhaber, Samuel Z.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Goldhaber, Samuel Z.
Haas, Sylvia
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Haas, Sylvia
Huisman, Menno V.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Huisman, Menno V.
Hull, Russel D.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Hull, Russel D.
Kakkar, Ajay K.
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Kakkar, Ajay K.
Misselwitz, Frank
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
Misselwitz, Frank
Schellong, Sebastian
论文数: 0引用数: 0
h-index: 0
机构:Univ Perugia, Osped S Maria Misercordia, Div Internal & Cardiovasc Med, I-06100 Perugia, Italy
机构:
Univ Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, ItalyUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Agnelli, Giancarlo
Buller, Harry R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, NetherlandsUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Buller, Harry R.
Cohen, Alexander
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, London, EnglandUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Cohen, Alexander
Curto, Madelyn
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Curto, Madelyn
Gallus, Alexander S.
论文数: 0引用数: 0
h-index: 0
机构:
Flinders Med Ctr, Dept Haematol, Adelaide, SA, Australia
Flinders Univ S Australia, Adelaide, SA 5001, AustraliaUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Gallus, Alexander S.
Johnson, Margot
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Johnson, Margot
Masiukiewicz, Urszula
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Masiukiewicz, Urszula
Pak, Raphael
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Pak, Raphael
Thompson, John
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Inc, Groton, CT 06340 USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Thompson, John
Raskob, Gary E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USAUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
Raskob, Gary E.
Weitz, Jeffrey I.
论文数: 0引用数: 0
h-index: 0
机构:
McMaster Univ, Dept Med, Hamilton, ON, Canada
McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada
Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, CanadaUniv Perugia, Internal & Cardiovasc Med Stroke Unit, I-06100 Perugia, Italy
机构:
Flinders Med Ctr, Adelaide, SA, Australia
Flinders Univ S Australia, Dept Haematol, Adelaide, SA 5001, AustraliaUniv Perugia, Dept Internal & Cardiovasc Med, Stroke Unit, I-06100 Perugia, Italy