Seven Fatty Acid Metabolism-Related Genes as Potential Biomarkers for Predicting the Prognosis and Immunotherapy Responses in Patients with Esophageal Cancer

被引:3
作者
Guo, Ya [1 ]
Pan, Shupei [1 ]
Ke, Yue [1 ]
Pan, Jiyuan [1 ]
Li, Yuxing [1 ]
Ma, Hongbing [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Radiat Oncol, Xian 710004, Peoples R China
关键词
esophageal cancer (ESCA); The Cancer Genome Atlas (TCGA); fatty acid metabolism; prognosis; immunotherapy response; COLORECTAL-CANCER; EXPRESSION; SURVIVAL; CELLS; PROLIFERATION; OXIDATION;
D O I
10.3390/vaccines10101721
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Esophageal cancer (ESCA) is a major cause of cancer-related mortality worldwide. Altered fatty acid metabolism is a hallmark of cancer. However, studies on the roles of fatty acid metabolism-related genes (FRGs) in ESCA remain limited. Method: We identified differentially expressed FRGs (DE-FRGs). Then, the DE-FRGs prognostic model was constructed and validated using a comprehensive analysis. Moreover, the correlation between the risk model and clinical characteristics was investigated. A nomogram for predicting survival was established and evaluated. Subsequently, the difference in tumor microenvironment (TME) was compared between two risk groups. The sensitivity of key DE-FRGs to chemotherapeutic interventions and their correlation with immune cells were investigated. Finally, DEGs between two risk groups were measured and the prognostic value of key DE-FRGs in ESCA was confirmed in other databases. Results: A prognostic model was constructed based on seven selected DEG-FRGs. TNM staging and CD8+ T cells were significantly correlated with high-risk groups. Low-risk groups exhibited more infiltrated M0 macrophages, an activation of type II interferon (IFN-gamma) responses, and were found to be more suitable for immunotherapy. Seven key DE-FRGs with prognostic value were found to be considerably influenced by different chemotherapy drugs. Conclusion: A prognostic model based on seven DE-FRGs may efficiently predict patient prognosis and immunotherapy response, helping to develop individualized treatment strategies in ESCA.
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页数:18
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