For three European states in particular, the Covid-19 pandemic has served to catalyze pre-existing territorial disputes. While the United Kingdom, Spain, and Belgium have all had very different responses to the pandemic, in all three cases the actions of central and regional government have put existing structures of regional autonomy under strain. In Spain, the pandemic response has become intertwined with the Catalan independence debate (especially in disputes between pro-independence parties), and elsewhere in the country it has cemented co-operative relationships between moderate nationalists and the statewide left. In Belgium, the pandemic has accentuated territorial disputes and further complicated government formation. And in the UK diverging responses to the pandemic have helped boost nationalist movements in the devolved nations; particularly the cause of the Scottish National Party (SNP) and their ambitions to create an independent Scottish state. While the year has been highly significant for secessionist movements in all three states, only in the UK does a decisive shift towards state-breakup seem to have occurred. The article argues that whether or not a secessionist movement benefits from the pandemic is highly contingent on contextual factors, including the performance of state-level governments in responding to the pandemic and the relative autonomy of regional governments during the response.