Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective

被引：25
作者：
Fragiotta, Serena [1 ]
Scuderi, Luca [2 ]
Iodice, Clemente Maria [1 ]
Rullo, Daria [1 ]
Di Pippo, Mariachiara [1 ]
Maugliani, Elisa [1 ]
Abdolrahimzadeh, Solmaz [2 ]
机构：
[1] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sense Organs NESMOS, Ophthalmol Unit, St Andrea Hosp, I-00189 Rome, Italy
[2] Univ Sapienza Rome, Dept Sense Organs, I-00161 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期
关键词：
choroid; retina; age-related macular degeneration; choroidal vascularity index; aging; OPTICAL COHERENCE TOMOGRAPHY; RETINAL-PIGMENT EPITHELIUM; COMPLEMENT FACTOR-H; SUBRETINAL DRUSENOID DEPOSITS; SWEPT-SOURCE; RETICULAR PSEUDODRUSEN; BRUCHS MEMBRANE; GEOGRAPHIC ATROPHY; VASCULARITY INDEX; HUMAN CHORIOCAPILLARIS;
D O I：
10.3390/ijms231912010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch's membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development.
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页数：17
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