Expression of protease-activated receptor 1 in oral squamous cell carcinoma

被引：38

作者：

Liu, YN

Gilcrease, MZ

Henderson, Y

Yuan, XH

Clayman, GL

Chen, Z

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2001年 / 169卷 / 02期

关键词：

protease-activated receptor; thrombin; squamous cell carcinoma; matrix metalloproteinase; metastasis;

D O I：

10.1016/S0304-3835(01)00504-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in nonmetastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：173 / 180

页数：8

共 27 条

[1] Signal characteristics of G protein-transactivated EGF receptor [J].