Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori

被引：8

作者：

dos Santos, Monica Pezenatto ^{[1
]}

Pereira, Jessica Nunes ^{[1
]}

De Labio, Roger Willian ^{[1
]}

Carneiro, Lilian Carla ^{[2
]}

Pontes, Jaqueline Correia ^{[2
]}

Barbosa, Monica Santiago ^{[2
]}

Cardoso Smith, Marilia De Arruda ^{[3
]}

Marques Payao, Spencer Luiz ^{[1
]}

Rasmussen, Lucas Trevizani ^{[4
]}

机构：

[1] Marilia Med Sch FAMEMA, Genet Lab, Lourival Freire 240, BR-17519050 Marilia, SP, Brazil

[2] Fed Univ Goias UFG, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil

[3] Fed Univ Sao Paulo UNIFESP, Morphol Dept, Sao Paulo, Brazil

[4] Marilia Med Sch FAMEMA, Biochem Dept, Lourival Freire 240, BR-17519050 Marilia, SP, Brazil

来源：

JOURNAL OF GASTROINTESTINAL CANCER | 2021年 / 52卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Gastric disease; Gastric Cancer; miRNA-125a-5p; Helicobacter pylori; HELICOBACTER-PYLORI; DOWN-REGULATION; MICRORNAS;

D O I：

10.1007/s12029-020-00432-w

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. pylori. Methods Patients were divided in groups according to histopathological analysis (control, gastritis, and cancer groups). Polymerase chain reaction was performed to detect H. pylori and real-time quantitative PCR to determine miR-125a-5p expression. Results H. pylori was detected in 44% of the patients, with prevalence in the gastritis and cancer groups. A statistically significant decrease of miR-125a-5p expression was found in the control positive (p = 0.0183*), gastritis positive (p = 0.0380*), and cancer positive (p = 0.0288*) groups when compared with the control negative group. Conclusion We suggest that decreased expression of the miRNA-125a-5p associated with the presence of the H. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer.

引用

页码：569 / 574

页数：6

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