The Role of Morphine in a Rat Model of Hypoxic-ischemic Injury

被引:8
作者
Festekjian, Ara [1 ]
Ashwal, Stephen [2 ]
Obenaus, Andre [2 ,3 ,4 ,5 ]
Angeles, Danilyn M. [6 ,7 ]
Denmark, T. Kent [1 ]
机构
[1] Loma Linda Univ, Dept Emergency Med, Div Pediat Emergency Med, Childrens Hosp, Loma Linda, CA 92350 USA
[2] Loma Linda Univ, Dept Pediat, Childrens Hosp, Loma Linda, CA 92350 USA
[3] Loma Linda Univ, Med Ctr, Dept Radiat Med, Loma Linda, CA USA
[4] Loma Linda Univ, Dept Radiol, Loma Linda, CA 92350 USA
[5] Loma Linda Univ, Dept Biophys & Bioengn, Loma Linda, CA 92350 USA
[6] Loma Linda Univ, Dept Physiol, Med Ctr, Loma Linda, CA 92350 USA
[7] Loma Linda Univ, Med Ctr, Dept Pharmacol, Loma Linda, CA USA
关键词
OPIOID RECEPTORS; CEREBRAL-ISCHEMIA; HYPOTHERMIA;
D O I
10.1016/j.pediatrneurol.2011.04.004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We investigated whether morphine plays a neuroprotective role in a neonatal rat pup model of bilateral carotid artery occlusion with hypoxia. At postnatal day 10, rats received either morphine (n = 7), naloxone (n = 7), or saline placebo (n = 15) after hypoxic-ischemic injury. Survival (days), weight gain and animal testing (negative geotaxis, surface righting, and rotarod) were compared between treatment groups. Lesion volume was delineated with magnetic resonance imaging at days 7 and 28-57 after injury. Survival in rats treated with morphine, naloxone, or saline was, respectively, 14, 29, and 73%. Median number of days of survival after bilateral carotid artery occlusion with hypoxia treated with morphine was 4 (95% confidence interval 4 to 22), with naloxone was 3 (95% confidence interval -1.4 to 21), and with placebo was 28 (95% confidence interval 18 to 28). There were no statistically significant differences in magnetic resonance imaging-derived ischemic lesion volumes, weight gain, or behavioral testing measures between the groups. Morphine was ineffective as a neuroprotectant in rat pups with severe hypoxic-ischemic injury and may have contributed to their decreased survival. Published by Elsevier Inc.
引用
收藏
页码:77 / 82
页数:6
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