TPR proteins: the versatile helix

被引：911
作者：
D'Andrea, LD
Regan, L
机构：
[1] CNR, Inst Biostruct & Bioimaging, I-80134 Naples, Italy
[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA
[3] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 12期
关键词：
D O I：
10.1016/j.tibs.2003.10.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tetratrico peptide repeat (TPR) proteins have several interesting properties, including their folding characteristics, modular architecture and range of binding specificities. In the past five years, many 3D structures of TPR domains have been solved, revealing at a molecular level the versatility of this basic fold. Here, we discuss the structure of TPRs and highlight the diversity of arrangements and functions that are associated with these ubiquitous domains. Genomic analyses of the distribution of TPR domains are presented along with implications for protein engineering.
引用
收藏
页码：655 / 662
页数：8
相关论文
共 40 条
[21]   Recent improvements to the SMART domain-based sequence annotation resource [J].
Letunic, I ;
Goodstadt, L ;
Dickens, NJ ;
Doerks, T ;
Schultz, J ;
Mott, R ;
Ciccarelli, F ;
Copley, RR ;
Ponting, CP ;
Bork, P .
NUCLEIC ACIDS RESEARCH, 2002, 30 (01) :242-244
[22]   Design of stable α-helical arrays from an idealized TPR motif [J].
Main, ERG ;
Xiong, Y ;
Cocco, MJ ;
D'Andrea, L ;
Regan, L .
STRUCTURE, 2003, 11 (05) :497-508
[23]   RASTER3D VERSION-2.0 - A PROGRAM FOR PHOTOREALISTIC MOLECULAR GRAPHICS [J].
MERRITT, EA ;
MURPHY, MEP .
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :869-873
[24]  
NICHOLLS A, 1993, BIOPHYS J, V64, pA166
[25]   A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains [J].
OwensGrillo, JK ;
Czar, MJ ;
Hutchison, KA ;
Hoffman, K ;
Perdew, GH ;
Pratt, WB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (23) :13468-13475
[26]  
Prapapanich V, 1996, MOL CELL BIOL, V16, P6200
[27]   Rapid grid-based construction of the molecular surface and the use of induced surface charge to calculate reaction field energies: Applications to the molecular systems and geometric objects [J].
Rocchia, W ;
Sridharan, S ;
Nicholls, A ;
Alexov, E ;
Chiabrera, A ;
Honig, B .
JOURNAL OF COMPUTATIONAL CHEMISTRY, 2002, 23 (01) :128-137
[28]   Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine [J].
Scheufler, C ;
Brinker, A ;
Bourenkov, G ;
Pegoraro, S ;
Moroder, L ;
Bartunik, H ;
Hartl, FU ;
Moarefi, I .
CELL, 2000, 101 (02) :199-210
[29]   SMART: a web-based tool for the study of genetically mobile domains [J].
Schultz, J ;
Copley, RR ;
Doerks, T ;
Ponting, CP ;
Bork, P .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :231-234
[30]   P62CDC23 OF SACCHAROMYCES-CEREVISIAE - A NUCLEAR TETRATRICOPEPTIDE REPEAT PROTEIN WITH 2 MUTABLE DOMAINS [J].
SIKORSKI, RS ;
MICHAUD, WA ;
HIETER, P .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (02) :1212-1221
1234