Direct benzylic alkylation via Ni-catalyzed selective benzylic sp3 C-O activation

被引：172

作者：

Guan, Bing-Tao ^{[1
,2
]}

Xiang, Shi-Kai ^{[1
,2
,3
]}

Wang, Bi-Qin ^{[1
,2
,3
]}

Sun, Zuo-Peng ^{[1
,2
,3
]}

Wang, Yang ^{[4
]}

Zhao, Ke-Qing ^{[3
]}

Shi, Zhang-Jie ^{[1
,2
,5
]}

机构：

[1] Peking Univ, Coll Chem, Minist Educ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China

[3] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 410066, Sichuan, Peoples R China

[4] China Agr Univ, Dept Chem, Beijing 100094, Peoples R China

[5] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 11期

关键词：

D O I：

10.1021/ja710944j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article demonstrates the first cross coupling of benzyl ether with Grignard reagents via Ni-catalyzed benzylic sp(3) C-O activation with high efficiency and excellent chemoselectivity. Benzylic sp(3) C-O and aryl sp(2) C-O were differentiated, controlled by ligands.

引用

页码：3268 / +

页数：3

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