Successful Treatment of Relapsing Bowen's Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response

被引：4

作者：

Mainetti, Carlo ^{[1
]}

Guillod, Caroline ^{[1
]}

Leoni-Parvex, Sandra ^{[2
]}

机构：

[1] Osped Reg Bellinzona & Valli, Dept Dermatol, CH-6500 Bellinzona, Switzerland

[2] Inst Pathol, Locarno, Switzerland

来源：

DERMATOLOGY | 2016年 / 232卷

关键词：

Ingenol mebutate; Bowen's disease; Dermoscopy; Non-melanoma skin cancers; ACTINIC KERATOSIS; GEL; GUIDELINES; MANAGEMENT; CARCINOMA;

D O I：

10.1159/000447389

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ingenol mebutate (IM) has recently been approved for the topical treatment of actinic keratoses. It appears to have a dual mechanism of action: rapid necrosis after gel application and a subsequent immune-mediated response, which targets any residual dysplastic epidermal cells. We report the successful treatment of a woman, who had been relapsing into Bowen's disease (BD) on her right forefinger for 8 years. During her clinical history, she had received an allogeneic, HLA-identical stem cell transplant for myeloproliferative syndrome with a JAK2V617F mutation and lobectomy of the pulmonary right lower lobe for adenocarcinoma. We used dermoscopy to monitor the therapeutic response of BD. We discuss IM gel as a possible therapeutic option for BD. (C) 2016 S. Karger AG, Basel

引用

页码：9 / 13

页数：5

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