Comparison of thyroid function in pregnant and non-pregnant Asian and western Caucasian women

被引:43
作者
Price, A
Obel, O
Cresswell, J
Catch, I
Rutter, S
Barik, S
Heller, SR
Weetman, AP
机构
[1] No Gen Hosp NHS Trust, Dept Clin Chem, Sheffield S5 7AU, S Yorkshire, England
[2] Univ London St Georges Hosp, Sch Med, Dept Cardiol Sci, London, England
[3] Chesterfield Royal Hosp, Dept Obstet & Gynaecol, Chesterfield, England
[4] No Gen Hosp NHS Trust, Dept Obstet & Gynaecol, Sheffield S5 7AU, S Yorkshire, England
[5] Dept Obstet & Gynaecol, Kolkata, W Bengal, India
[6] No Gen Hosp NHS Trust, Dept Med, Sheffield S5 7AU, S Yorkshire, England
关键词
thyroid function tests; ethnic differences; pregnancy; Asian; Caucasian;
D O I
10.1016/S0009-8981(01)00470-3
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Gestational thyrotoxicosis may be more prevalent in Asian women. Methods We have measured thyroid function, ferritin and bone specific alkaline phosphatase (BALP) as peripheral markers of thyroid function and hCG in Asian and western Caucasian women in non-pregnant and early pregnancy. Results: TSH was lower in Asian women in non-pregnancy but not during normal pregnancy and this may reflect increased sensitivity of the thyroid gland to thyroid stimulation in the Asian population. No ethnic difference was found in FT3, FT4 or hCG but ferritin was lower and BALP higher in Asian women whether pregnant or not and this may be a reflection of iron balance and vitamin D status. Conclusions: We found during normal pregnancy that dynamic patterns of change for thyroid hormones and hCG are not different in Asian and western Caucasian women. We have developed gestation related reference intervals. which are a pre-requisite to the study of ethnic differences in gestation thyrotoxicosis in pregnancy. (C) 2001 Elsevier science B.V. All rights reserved.
引用
收藏
页码:91 / 98
页数:8
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