Synthesis, immunomodulating effects and structure-activity relationships of new N-phenyl-5-amino-3-methylisoxazole-4-carboxamides

被引:38
作者
Ryng, S
Machon, Z
Wieczorek, Z
Zimecki, M
Mokrosz, M
机构
[1] Univ Med, Fac Pharm, Dept Organ Chem, PL-50137 Wroclaw, Poland
[2] Polish Acad Sci, Inst Immunol & Expt Therapy, Dept Expt Therapy, PL-53114 Wroclaw, Poland
[3] Polish Acad Sci, Inst Pharmacol, Dept Med Chem, PL-31343 Krakow, Poland
关键词
isoxazoles; N-phenyl-5-amino-3-methylisoxazole-4-carboxamides; immunological activity; structure-activity relationships;
D O I
10.1016/S0223-5234(99)80035-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:831 / 836
页数:6
相关论文
共 16 条
[1]   IMMUNOPHARMACOLOGICAL PROFILE OF HWA-486, A NOVEL ISOXAZOL DERIVATIVE .2. INVIVO IMMUNOMODULATING EFFECTS DIFFER FROM THOSE OF CYCLOPHOSPHAMIDE, PREDNISOLONE, OR CYCLOSPORINE-A [J].
BARTLETT, RR .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1986, 8 (02) :199-204
[2]  
BARTLETT RR, 1991, AGENTS ACTIONS, V1, P32
[3]   Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro [J].
Chong, ASF ;
Rezai, K ;
Gebel, HM ;
Finnegan, A ;
Foster, P ;
Xu, XL ;
Williams, JW .
TRANSPLANTATION, 1996, 61 (01) :140-145
[4]  
FURST DE, 1995, BAILLIERE CLIN RHEUM, V9, P711
[5]  
GEORGIEV VS, 1988, TRENDS PHARMACOL SCI, V9, P446
[6]   IMMUNOSTIMULANTS (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 169-174, 1993) [J].
HADDEN, JW .
IMMUNOLOGY TODAY, 1993, 14 (06) :275-280
[7]   INFLUENCE OF DOSE AND ROUTE OF ANTIGEN INJECTION ON IMMUNOLOGICAL INDUCTION OF T-CELLS [J].
LAGRANGE, PH ;
MACKANESS, GB ;
MILLER, TE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1974, 139 (03) :528-542
[8]  
MACHON Z, 1981, ARCH IMMUNOL THER EX, V29, P813
[9]   IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE [J].
MISHELL, RI ;
DUTTON, RW .
JOURNAL OF EXPERIMENTAL MEDICINE, 1967, 126 (03) :423-&
[10]  
MOSSMANN TR, 1989, ADV IMMUNOL, V46, P111