Significantly increased frequency of the apolipoprotein E epsilon 4 allele in elderly non-demented leprosy patients

被引：6
作者：
Endoh, M
Ueki, A
Takahashi, K
Yamanaka, H
Izumi, S
Tabira, T
机构：
[1] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV DEMYELINATING DIS & AGING,KODAIRA,TOKYO 187,JAPAN
[2] NATL INST LEPROSY RES,DEPT BIOREGULAT,HIGASHIMURAYAMA,TOKYO 189,JAPAN
[3] OMIYA MED CTR,JICHI MED SCH,DEPT NEUROL,OMIYA,SAITAMA 330,JAPAN
来源：
NEUROSCIENCE LETTERS | 1996年 / 207卷 / 03期
关键词：
leprosy; apolipoprotein E; Alzheimer's disease; dementia; 4,4'-diaminodiphenyl sulfone;
D O I：
10.1016/0304-3940(96)12513-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Apolipoprotein E (apo E) genotypes in 350 leprosy patients were examined and compared with those of 870 age-matched controls. The allelic frequencies of the apo E gene did not differ between demented patients with leprosy and controls. However, the frequency of apo E epsilon 4 allele was significantly higher in non-demented leprosy patients than in controls (P < 0.001). Of special interest is that the prevalence of E3/4 genotype in non-demented leprosy patients increased significantly with age, being 14.1%, 24.4%, and 28.3% in the 60s, 70s, and 80s, respectively (P < 0.05). These data suggest that apo E epsilon 4 is not a risk factor for senile dementia in elderly leprosy patients, and there exist factors to overcome the risk of apo E4 in leprosy patients.
引用
收藏
页码：206 / 208
页数：3
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