Pharmacological properties of Anagallis arvensis L. ("scarlet pimpernel") and Anagallis foemina Mill. ("blue pimpernel") traditionally used as wound healing remedies in Navarra (Spain)

Ethnopharmacological relevance: : Anagallis arvensis and Anagallis foemina are traditionally used in Navarra (Spain) for dermatological purposes regarding wound healing properties. In some cases they are also used to threat internal infections although they are known to be toxic at high doses. Aim of study:: Due to lack of studies, we decided to evaluate the potential of the plants as wound healing remedies measuring antimicrobial and anti-inflammatory properties using in vitro procedures. Materials and methods: Antimicrobial effects were studied against four bacteria and one fungus. Antiinflammatory properties were measured in terms of COX-1 and -2 inhibition as well as superoxide radical scavenging capacity. Results: Both species exerted antimicrobial and anti-inflammatory effects. The methanolic extract obtained from Anagallis arvensis seemed to produce the highest inhibition in Candida albicans (MIC = 0.31 mg/ml). Inhibition of COX-1 and -2 was also stronger for methanolic extracts whereas aqueous were revealed as better free radical scavengers. Conclusions: The study reveals that both species posses antimicrobial and anti-inflammatory activities related to their ethnomedicinal uses. (C) 2011 Elsevier Ireland Ltd. All rights reserved.