Ru(II)-Catalyzed Oxidative Spiroannulation of 2-Arylphenols with Alkynes via a C-H Activation/Dearomatization Strategy

被引：62
|
作者：
Zuo, Zhijun [1 ]
Yang, Xin [1 ]
Liu, Jingjing [1 ]
Nan, Jiang [1 ]
Bai, Lu [1 ]
Wang, Yaoyu [1 ]
Luan, Xinjun [1 ]
机构：
[1] NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Coll Chem & Mat Sci, Xian 710069, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 06期
基金：
美国国家科学基金会;
关键词：
ASYMMETRIC ALLYLIC DEAROMATIZATION; PALLADIUM-CATALYZED SYNTHESIS; BOND ACTIVATION; INTERNAL ALKYNES; ISOQUINOLINIUM SALTS; PYRROLE SYNTHESIS; ANNULATION; PHENOLS; FUNCTIONALIZATION; CLEAVAGE;
D O I：
10.1021/acs.joc.5b00316
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.
引用
收藏
页码：3349 / 3356
页数：8
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