How the worm removes corpses:: the nematode C-elegans as a model system to study engulfment

被引:46
作者
Gumienny, TL
Hengartner, MO
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA
关键词
apoptosis; phagocytosis; cell migration; genetics; rac;
D O I
10.1038/sj.cdd.4400850
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Apoptotic with the removal of the dying cells from the organism. This removal is brought forth through a rapid and specific engulfment of the doomed cell by one of its neighbors. Over half a dozen genes have been identified that function in this process in the worm. Many of these engulfment genes have functional homologs in Drosophila and higher vertebrates. Indeed, there is growing evidence supporting the hypothesis that the pathways that mediate the removal of apoptotic cells might be, at least in part, conserved through evolution.
引用
收藏
页码:564 / 568
页数:5
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