Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension

被引：7

作者：

de Beus, Esther ^{[1
]}

de Jager, Rosa L. ^{[1
]}

Beeftink, Martine M. ^{[2
]}

Sanders, Margreet F. ^{[1
]}

Spiering, Wilko ^{[3
]}

Vonken, Evert-Jan ^{[4
]}

Voskuil, Michiel

Bots, Michiel L. ^{[5
]}

Blankestijn, Peter J. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Cardiol, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Vasc Med, Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Radiol, Utrecht, Netherlands

[5] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2017年 / 19卷 / 11期

关键词：

dietary sodium; hypertension; renal denervation; salt sensitivity; sodium intake; SYMPATHETIC-NERVOUS-SYSTEM; URINARY SODIUM; POTASSIUM EXCRETION; SPIRONOLACTONE; METAANALYSIS; ASSOCIATION;

D O I：

10.1111/jch.13085

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The effect of lowering sympathetic nerve activity by renal denervation (RDN) is highly variable. With the exception of office systolic blood pressure (BP), predictors of the BP-lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24-hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension. Both 24-hour ambulatory and office BP measurements were end points. No relationship was found for baseline sodium excretion and change in BP 6months after RDN in multivariable-adjusted regression analysis. Change in the salt intake-measured BP relationships at 6months vs baseline was used as a measure for salt sensitivity. BP was 8mmHg lower with similar salt intake after RDN, suggesting a decrease in salt sensitivity. However, the change was similar in the control group, and thus not attributable to RDN.

引用

页码：1125 / 1133

页数：9

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