ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses

被引：5

作者：

Keegan, Liam P. ^{[1
]}

Vukic, Dragana ^{[1
]}

O'Connell, Mary A. ^{[1
]}

机构：

[1] CEITEC Masaryk Univ, Kamenice 735-5,A35, CZ-62500 Brno, Czech Republic

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 11期

关键词：

Z-ALPHA DOMAIN; DEAMINASE ADAR1; RNA; MUTATIONS; ACTIVATION; PKR;

D O I：

10.1016/j.it.2021.09.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

ADAR1 edits adenosines to inosines in cellular double-stranded (ds) RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutieres syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al., Maurano et al., and de Reuver et al. demonstrated that Adar1 Z alpha domain-mutant mice show aberrant MDA5 and PKR activation, developing encephalopathies; short Z-RNA patches within cellular dsRNA are unexpectedly crucial in causing aberrant antiviral responses.

引用

页码：953 / 955

页数：3

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